Autor(es): Grotto, Rejane Maria Tommasini [UNESP] ; Santos, Francielle Martins [UNESP] ; Picelli, Natália [UNESP] ; Silva, Giovanni Faria [UNESP] ; Ferrasi, Adriana Camargo [UNESP] ; Sarnighausen, Valéria Cristina Rodrigues [UNESP] ; Pardini, Maria Inês de Moura Campos [UNESP]
Data: 2019
Identificador Persistente: http://hdl.handle.net/11449/189420
Origem: Oasisbr
Assunto(s): Hepatitis C virus; Hepatocellular carcinoma; Human platelets antigens
Made available in DSpace on 2019-10-06T16:40:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01. Added 1 bitstream(s) on 2019-10-09T18:35:32Z : No. of bitstreams: 1 S0037-86822019000100666.pdf: 992818 bytes, checksum: 0cfde2df6824e62405350047eb8793a4 (MD5)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Introduction: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. Methods: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. Results: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. Conclusions: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.
Laboratório de Biologia Molecular do Hemocentro Faculdade de Medicina de Botucatu Universidade Estadual Paulista
Universidade Estadual Paulista (UNESP) Faculdade de Ciências Agronômicas Departamento de Bioprocessos e Biotecnologia
Universidade Estadual Paulista (UNESP) Faculdade de Medicina Departamento de Clínica Médica
Laboratório de Biologia Molecular do Hemocentro Faculdade de Medicina de Botucatu Universidade Estadual Paulista
Universidade Estadual Paulista (UNESP) Faculdade de Ciências Agronômicas Departamento de Bioprocessos e Biotecnologia
Universidade Estadual Paulista (UNESP) Faculdade de Medicina Departamento de Clínica Médica
FAPESP: 2014/20645-9
