Descrição
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions from the growth medium of Penicillium solitum IS1-A provided the new glutamic acid derivatives solitumine A (1), solitumine B (2), and solitumidines A-D (3-6). The structures of compounds 1-6 have been established by analysis of spectroscopic data, chemical derivatizations, and vibrational circular dichroism calculations. Although no biological activity could be observed for compounds 1-6, the new structures reported for 1-6 indicate that the investigation of water-soluble natural products represents a relevant strategy in finding new secondary metabolites.
Univ Sao Paulo, Inst Quim Sao Carlos, CP 780, BR-13560970 Sao Carlos, SP, Brazil
Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP, Brazil
Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro,Avenida 24-A,1515, Rio Claro, SP, Brazil
Univ Fed Sao Paulo, Inst Ciencia & Tecnol, BR-12231280 Sao Jose Dos Campos, SP, Brazil
Univ Franca, Nucleo Pesquisa Ciencia & Tecnol, Ave Dr Armando Salles Oliveira,201 Pq Univ, BR-14404600 Franca, SP, Brazil
Univ Sao Paulo, Dept Ciencias Exatas, Escola Super Agr Luiz de Queiroz, Agron, Ave Padua Dias 11,CP 9, BR-13418900 Piracicaba, SP, Brazil
Natl Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, Giuseppe Maximo Scolfaro 10000, BR-13083970 Campinas, SP, Brazil
Univ Estadual Campinas, Inst Biol, BR-13083862 Campinas, SP, Brazil
Univ Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, Campus Rio Claro,Avenida 24-A,1515, Rio Claro, SP, Brazil
FAPESP: 2013/50228-8
FAPESP: 2016/21341-9
FAPESP: 2017/06014-4
FAPESP: 2013/23153-7
FAPESP: 2016/16033-3
