Autor(es): de Almeida, Amanda Cosmo [UNESP] ; Ferreira, Patrícia Osório [UNESP] ; Torquetti, Carolina [UNESP] ; Ekawa, Bruno [UNESP] ; Carvalho, Ana Carina Sobral [UNESP] ; dos Santos, Everton Carvalho [UNESP] ; Caires, Flávio Junior [UNESP]
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/198126
Origem: Oasisbr
Assunto(s): Ciprofloxacin; Cocrystal; Mechanochemical synthesis; Thermal analysis
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.
Institute of Chemistry São Paulo State University (UNESP)
School of Sciences São Paulo State University (UNESP)
Institute of Chemistry São Paulo State University (UNESP)
School of Sciences São Paulo State University (UNESP)
CAPES: 001
FAPESP: 2013/09022-7
FAPESP: 2017/14936-9
FAPESP: 2018/12463-9
FAPESP: 2018/24378-6
