Autor(es): Faria, Flávia Rasmussen ; Gomes, Aline Corado ; Antunes, Alisson ; Rezende, Kênnia Rocha ; Pimentel, Gustavo Duarte ; Oliveira, Camila Lemos Pinto ; Antunes, Barbara Moura [UNESP] ; Lira, Fabio Santos [UNESP] ; Aoki, Marcelo Saldanha ; Mota, João Felipe
Data: 2020
Identificador Persistente: http://hdl.handle.net/11449/198797
Origem: Oasisbr
Assunto(s): Curcuma; Exercise; Inflammation; Muscle damage
Made available in DSpace on 2020-12-12T01:22:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-07-01
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Purpose: Strenuous exercise induces inflammation and muscle damage. Turmeric (Curcuma longa L.) is a widely used spice that exhibits potent anti-inflammatory response and appears to decrease indirect markers of muscle damage. A randomized, double-blind, placebo-controlled trial was conducted to evaluate the effects of Curcuma longa L. extract (CLE) on inflammation and muscle damage after a half-marathon race. Methods: Twenty-eight healthy, normal-weight men were randomly assigned to one of two groups: (1) CLE (3 capsules per day, 500 mg each); or (2) placebo (PLA, 3 capsules per day, 500 mg of microcrystalline cellulose). Participants received the intervention for 4 weeks and immediately before and after the half-marathon race. Creatine kinase, lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, myoglobin, interleukins 6 and 10 were assessed at baseline, immediately before, after, and at 2, 24, and 48 h after the half-marathon race. Results: The half-marathon race increased markers of inflammation and muscle damage. A greater increase in interleukin-10 was observed in the CLE group immediately after the competition compared to the PLA group (7.54 ± 1.45 vs 5.25 ± 0.59 pg/mL; p < 0.05; d = 0.55). Myoglobin concentration was lower 2 h after the race in participants from the CLE group compared to the PLA group (62.10 ± 8.26 vs 107.85 ± 18.45 ng/mL; p = 0.01; d = 0.86). Conclusion: Curcuma longa L. extract supplementation leads to an increase in IL-10 and decreased myoglobin in recreational male runners after a half-marathon race. Trial registration number: U1111-1179-6335, February 13, 2016.
Clinical and Sports Nutrition Research Laboratory (LABINCE) School of Nutrition Federal University of Goiás, St. 227, Block 68, Setor Leste Universitário
Laboratory of Biopharmacy and Pharmacokinetics Federal University of Goiás
Department of Agricultural Food and Nutritional Science Human Nutrition Research Unit Faculty of Agricultural Life and Environmental Sciences University of Alberta
Department of Physical Education Exercise and Immunometabolism Research Group São Paulo State University (UNESP)
School of Arts Sciences and Humanities University of São Paulo
Department of Physical Education Exercise and Immunometabolism Research Group São Paulo State University (UNESP)
CNPq: 484023/2013-6
