Autor(es): Fortaleza, Carlos Magno Castelo Branco [UNESP] ; Filho, Sebastião Pires Ferreira [UNESP] ; Silva, Marina de Oliveira [UNESP] ; Queiroz, Sandra Mara [UNESP] ; Cavalcante, Ricardo de Souza [UNESP]
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/205187
Origem: Oasisbr
Assunto(s): Bundle; Central line-associated bloodstream infections; Interrupted time series; Ventilator-associated pneumonia
Made available in DSpace on 2021-06-25T10:11:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01
Fundação de Amparo à Pesquisa do Estado de Alagoas
Background: Infection control interventions can be erroneously interpreted if outcomes are assessed in short periods. Also, statistical methods usually applied to compare outcomes before and after interventions are not appropriate for analyzing time series. Aims: To analyze the impact of a bundle directed at reducing the incidence of ventilator-associated pneumonia (VAP) and other device-associated infections in two medical-surgical intensive care units (ICU) in Brazil. Methods: Our study had a quasi-experimental design. Interrupted time series analyses (ITS) was performed assessing monthly rates of overall healthcare-associated infections (HCAI), VAP, laboratory-confirmed central line associated bloodstream infections (CLABSI) and catheter-associated urinary tract infections (CAUTI), from January 2007 through June 2019. Moreover, multivariate ITS was adjusted for seasonality in Poisson regression models. An intervention based on a bundle for VAP prevention was introduced in August 2010. Findings: The intervention was followed by sustained reduction in overall HCAI, VAP and CLABSI in both ICU. Continuous post-intervention trends towards reduction were detected for overall HCAI and VAP. Conclusion: Interventions aimed at preventing one specific site of infection may have sustained impact on other HCAI, which can be documented using time series analyses.
Universidade do Estado de São Paulo(UNESP) Faculdade de Medicina de Botucatu Department of Infectious Diseases
Universidade do Estado de São Paulo(UNESP) Faculdade de Medicina de Botucatu Department of Infectious Diseases
Fundação de Amparo à Pesquisa do Estado de Alagoas: 2015/06521-8
