Autor(es):
Augusto Ferreira Mota, Gustavo [UNESP] ; Luiz Borges de Souza, Sérgio [UNESP] ; Loureiro da Silva, Vitor [UNESP] ; Gatto, Mariana [UNESP] ; Henrique Salomé de Campos, Dijon [UNESP] ; Grippa Sant’Ana, Paula [UNESP] ; Vileigas, Danielle Fernandes [UNESP] ; Padovani, Carlos Roberto [UNESP] ; Casarini, Dulce Elena ; Menezes de Oliveira, Edilamar ; Garcia Zanati Bazan, Silméia [UNESP] ; Fernandes, Tiago ; Sugizaki, Mario Mateus [UNESP] ; Ricardo de Morais Gomes, Enéas [UNESP] ; Cicogna, Antonio Carlos
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/206496
Origem: Oasisbr
Assunto(s): Cardiac dysfunction; Cardiac remodeling; Cell cycle; Physical training; Renin-angiotensin system
Descrição
Made available in DSpace on 2021-06-25T10:33:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01
North Carolina Biotechnology Center
Background/Aims: The beneficial effect of aerobic exercise training (ET) on cardiac remodeling caused by supravalvar aortic stenosis (AS) has been demonstrated in experimental studies; however, the mechanisms responsible for improving cardiac function are not entirely understood. We evaluated whether ET-generated cardioprotection in pressure-overloaded rats is dependent on cardiomyocyte proliferation, increased angiotensin-(1-7) (Ang-1-7) levels, and its receptor in the myocardium. Methods: Eighteen weeks after ascending AS surgery, Wistar rats were randomly assigned to four groups: sedentary control (C-Sed), exercised control (C-Ex), sedentary aortic stenosis (AS-Sed) and exercised aortic stenosis (AS-Ex) groups. The moderate treadmill exercise protocol was performed for ten weeks. The functional capacity was assessed by treadmill exercise testing. Cardiac structure and function were evaluated by echo.
Department of Internal Medicine Botucatu Medical School São Paulo State University
Department of Biostatistics Institute of Bioscience São Paulo State University
Department of Medicine Nephrology Division Federal University of São Paulo
Laboratory of the Biochemistry and Molecular Biology of Exercise School of Physical
Education and Sport University of São Paulo
Department of Biotechnology Center
of Biotechnology Federal University of Paraíba
Department of Internal Medicine São Paulo State University - Unesp
District of Rubião Júnior, Av. Prof. Mário Rubens Guimarães Montenegro, S/N
Department of Internal Medicine Botucatu Medical School São Paulo State University
Department of Biostatistics Institute of Bioscience São Paulo State University
Department of Internal Medicine São Paulo State University - Unesp
