Autor(es): Lucio Filho, Carlos Eduardo Pinheiro [UNESP] ; Bertanha, Matheus [UNESP] ; Prata, Marcela Polachini [UNESP] ; Carvalho, Lídia Raquel de [UNESP] ; Jaldin, Rodrigo Gibin [UNESP] ; Sobreira, Marcone Lima [UNESP] ; Janzen, Jan [UNESP] ; Yoshida, Winston Bonetti [UNESP]
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/206630
Origem: Oasisbr
Assunto(s): animal models; efficacy; safety; sclerosing solutions; sclerotherapy; Varicose veins
Made available in DSpace on 2021-06-25T10:35:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01
Objective: To compare the efficacy and safety of sclerosing agents injected in dorsal veins of rabbit ears. Methods: Sixty ears of 30 rabbits were randomly allocated in: 1% liquid polidocanol, 1% polidocanol foam, 0.2% polidocanol-glucose 70% solution, glucose 75% or 0.9% saline. Outcomes included efficacy (luminal occlusion), complications (phlebitis, neovascularization, ulceration at the puncture site, necrosis and local inflammation) and histology (sclerosis, recanalization vein and surrounding tissues inflammation, blood extravasation, recanalization, lymphangiogenesis, destruction of cartilage and neoangiogenesis). Results: Sclerosis was superior in Foam Group (76.9%), but also with 30.7% necrosis (p = 0.003), 46.15% ulceration (p = 0.003), and 69.2% local inflammation (p < 0.0001). Neovascularization were similar. Histology showed 38.5% phlebitis (p = 0.004) and necrosis (p = 0.03) in the foam group. Conclusions: Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events.
Department of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP
Department of Biostatistics-Biosciences Institute Paulista State University UNESP
Histopathologie und VascPath
Department of Surgery and Orthopedics School of Medicine of Botucatu Paulista State University UNESP
Department of Biostatistics-Biosciences Institute Paulista State University UNESP
