Autor(es): Sant'Anna, Paula Bilbau [UNESP] ; Da Silva Trindade, Fabricio ; Geraldes, Silvano Salgueiro [UNESP] ; De Azevedo, Maria Gabriela Picelli [UNESP] ; Hataka, Alessandre [UNESP] ; Paes, Antonio Carlos [UNESP] ; Melchert, Alessandra [UNESP] ; Guimaraes-Okamoto, Priscylla Tatiana Chalfun [UNESP]
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/207783
Origem: Oasisbr
Assunto(s): Amyloidosis; Dogs; Glomerulocystic; Glomerulopathy; Glomerulus
Made available in DSpace on 2021-06-25T11:00:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01
This study aims at assessing the prevalence of glomerular alterations in dogs with chronic kidney disease (CKD) and comparing the clinical and laboratory parameters. The tests conducted include a double-blind histopathological assay conducted by two pathologists, urine tests including inactive sediment, urinary protein-to-creatinine (UPC), serum albumin and serum creatinine, as well as measurement of the systolic arterial blood pressure. The prevalence of glomerular injuries was determined and the predominant injury was compared with a group comprised of the remaining injuries. The study included 24 dogs with CKD. The results revealed a predominance of membranous glomerular alterations 17/24 (70, 83%), followed by glomerulosclerosis 3/24 (12, 50%), membranoproliferative injuries 2/24, glomerulocystic atrophy 1/24 and glomerular amyloidosis 1/24. Amyloidosis presented the highest UPC while the membranoproliferative injury presented the lowest mean concentration of serum albumin. Higher values in the UPC did not correspond with lower mean serum albumin values. Glomerulosclerosis presented the highest mean systolic blood pressure and glomerular atrophy presented the highest creatinine values. When comparing membranous injuries with a group comprised of the remaining injuries, the UPC did not present significant differences between the groups. Renal amyloidosis was included in the group with the lowest systolic arterial blood pressure values while membranoproliferative injury was included in the group with highest UPC. The group called others presented the highest creatinine value. Dogs with CKD may present several types of glomerular injuries with similar clinical and laboratory profiles. This study observed a predominance of membranous glomerular injuries, followed by membranoproliferative injuries, glomerulocystic atrophy and amyloidosis.
Veterinary Medicine Program in School of Veterinary Medicine and Animal Sciences Universidade Estadual de São Paulo UNESP
Veterinary Pathologist
Depatment of Veterinary Clinic in School of Veterinary Medicine and Animal Sciences UNESP
Depatment of Vet. Hygiene and Public Health in School of Veterinary Medicine and Animal Science UNESP
Veterinary Medicine Program in School of Veterinary Medicine and Animal Sciences Universidade Estadual de São Paulo UNESP
Depatment of Veterinary Clinic in School of Veterinary Medicine and Animal Sciences UNESP
Depatment of Vet. Hygiene and Public Health in School of Veterinary Medicine and Animal Science UNESP
