Author(s): Santos, Thaís Aguiar [UNESP] ; Scorzoni, Liliana [UNESP] ; Santos, Aline de Castro [UNESP] ; Junqueira, Juliana Campos [UNESP] ; Anbinder, Ana Lia [UNESP]
Date: 2021
Persistent ID: http://hdl.handle.net/11449/208195
Origin: Oasisbr
Subject(s): Aggregatibacter actinomycetemcomitans; Fusobacterium nucleatum; Galleria mellonella; Periodontal diseases; Porphyromonas gingivalis
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
In the present study, Galleria mellonella was evaluated as a potential infection model for periodontal bacteria, more specifically, Porphyromonas gingivalis, Fusobacterium nucleatum, and Aggregatibacter actinomycetemcomitans. All the bacteria evaluated were pathogenic to G. mellonella, causing their death in a concentration-dependent manner, and a decrease in their hemocyte count. Moreover, it was possible to recover the bacteria from the larvae hemolymph and determine the colony-forming units per larvae. G. mellonella is an effective model that may help to better understand the host-microbe interactions in periodontics.
Department of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)
Department of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University (Unesp)
FAPESP: 2016/06946-1
FAPESP: 2017/05439-1
