Autor(es):
Mendonça, Michelle M. ; Costa, Amanda N. ; Moraes, Gean C.A. ; Martins, Gustavo M. ; Almeida, Aline F. ; Rincon, Gabriel C.N. ; Siqueira, João P.R. ; Padilha, Daniella M. ; Moya, Marcela I. ; Ferreira-Neto, Marcos L. ; Gomes, Rodrigo Mello ; Pedrino, Gustavo Rodrigues ; Fontes, Marco Antônio Peliky ; Colombari, Eduardo [UNESP] ; Crestani, Carlos C. [UNESP] ; Fajemiroye, James O. ; Xavier, Carlos Henrique
Data: 2021
Identificador Persistente: http://hdl.handle.net/11449/208462
Origem: Oasisbr
Assunto(s): arousal; defense reactions; heart rate; hypertension; stress
Descrição
Made available in DSpace on 2021-06-25T11:12:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01
Clonidine (CL) and Rilmenidine (RI) are among the most frequently prescribed centrally acting antihypertensives. Here, we compared CL and RI effects on psychogenic cardiovascular reactivity to sonant, luminous, motosensory, and vibrotactile stimuli during neurogenic hypertension. The femoral artery and vein of Wistar (WT – normotensive) and spontaneously hypertensive rats (SHR) were catheterized before (24 h interval) i.p. injection of vehicle (NaCl 0.9%, control - CT group), CL (10 µg/kg), or RI (10 µg/kg) and acute exposure to luminous (5000 lm), sonant (75 dB sudden tap), motor (180° cage twist), and air-jet (10 L/min – restraint and vibrotactile). Findings showed that: (i) CL or RI reduced the arterial pressure of SHR, without affecting basal heart rate in WT and SHR; (ii) different stimuli evoked pressor and tachycardic responses; (iii) CL and RI reduced pressor response to sound; (iv) CL or RI reduced pressor responses to luminous stimulus without a change in peak tachycardia in SHR; (v) cage twist increased blood pressure in SHR, which was attenuated by CL or RI; (vi) air-jet increased pressure and heart rate; (vii) CL or RI attenuated the pressor responses to air-jet in SHR while RI reduced the chronotropic reactivity in both strains. Altogether, both antihypertensives relieved the psychogenic cardiovascular responses to different stimuli. The RI elicited higher cardioprotective effects through a reduction in air-jet-induced tachycardia.
Institute of Biological Sciences Federal University of Goias
School of Medicine Federal University of Goias
Institute of Biomedical Sciences Federal University of Uberlandia
Institute of Biological Sciences Federal University of Minas Gerais
School of Dentistry São Paulo State University (UNESP)
School of Pharmaceutical Sciences São Paulo State University (UNESP)
School of Dentistry São Paulo State University (UNESP)
School of Pharmaceutical Sciences São Paulo State University (UNESP)
