Autor(es): Rocha, Mackson Martins ; Dariva, Isabela ; Zornoff, Gabriela Comelli ; De Laurentis, Giovanna Sanches ; Mendes, Giulia Carli ; Santana, Maycon Giovani ; Miguel, Guilherme Chohfi de ; Ferreira, Rui Seabra [UNESP] ; Sciani, Juliana Mozer ; Priolli, Denise Goncalves
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/218845
Origem: Oasisbr
Assunto(s): Bone metastasis; Melittin; Intratumoral injection; Colorectal neoplasms; Bee venom
Made available in DSpace on 2022-04-28T17:23:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-14
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the metastasis skeletal-related impact in colorectal cancer patients with bone metastasis.
Sao Francisco Univ, Multidisciplinary Lab, Postgrad Program Hlth Sci, Braganca Paulista, SP, Brazil
Sao Francisco Univ, Med Sch, Braganca Paulista, SP, Brazil
Sao Francisco Univ, Nursing Sch, Braganca Paulista, SP, Brazil
Sao Paulo State Univ UNESP, Ctr Studies Venoms & Venomous Anim CEVAP, Botucatu, SP, Brazil
Sao Paulo State Univ UNESP, Ctr Studies Venoms & Venomous Anim CEVAP, Botucatu, SP, Brazil
FAPESP: 2018/21471-5
