Gender, body mass index and rheumatoid arthritis disease activity: Results from the QUEST-RA study

• Autor(es): Jawaheer, Damini ; Olsen, Jørn ; Lahiff, Maureen ; Forsberg, Sinikka ; Lähteenmäki, Jukka ; da Silveira, Ines Guimaraes ; Rocha, Francisco Airton ; Laurindo, Ieda Maria Magalhães [UNESP] ; da Mota, Licia Maria Henrique ; Drosos, Alexandros A. ; Murphy, Eithne ; Sheehy, Claire ; Quirke, Edel ; Cutolo, Maurizio ; Rexhepi, Sylejman ; Dadoniene, Jolanta ; Verstappen, Suzan M.M. ; Sokka, Tuulikki ; Toloza, Sergio ; Aguero, Santiago ; Barrera, Sergio Orellana ; Retamozo, Soledad ; Alba, Paula ; Lascano, Cruz ; Babini, Alejandra ; Albiero, Eduardo ; Pinheiro, Geraldo da Rocha Castelar ; Lazovskis, Juris ; Hetland, Merete Lund ; Ørnbjerg, Lykke ; Hørslev-Petersen, Kim ; Hansen, Troels Mørk ; Knudsen, Lene Surland ; Hamoud, Hisham ; Sobhy, Mohamad ; Fahmy, Ahmad ; Magdy, Mohamad ; Aly, Hany ; Saeid, Hatem ; Nagm, Ahmad ; Fathi, Nihal A. ; Abda, Esam ; Ebraheam, Zahra ; Müller, Raili ; Kuuse, Reet ; Tammaru, Marika ; Kallikorm, Riina ; Peets, Tony ; Otsa, Kati ; Laas, Karin ; Valter, Ivo ; Mäkinen, Heidi ; Immonen, Kai ; Luukkainen, Reijo ; Gossec, Laure ; Dougados, Maxime ; Maillefert, Jean Francis ; Combe, Bernard ; Sibilia, Jean ; Exarchou, Sofia ; Moutsopoulos, H. M. ; Tsirogianni, Afrodite ; Skopouli, Fotini N. ; Mavrommati, Maria ; Herborn, Gertraud ; Rau, Rolf ; Alten, Rieke ; Pohl, Christof ; Burmester, Gerd R. ; Marsmann, Bettina ; Géher, Pál ; Rojkovich, Bernadette ; Bresnihan, Barry ; Minnock, Patricia ; Devlin, Joe ; Alraqi, Shafeeq ; Aggarwal, Amita ; Pandya, Sapan ; Sharma, Banwari ; Cazzato, Massimiliano ; Bombardieri, Stefano ; Ferraccioli, Gianfranco ; Morelli, Alessia ; Salaffi, Fausto ; Stancati, Andrea ; Yamanaka, Hisashi ; Nakajima, Ayako ; Fukuda, Wataru ; Shono, Eisuke ; Oyoo, Omondi ; Rexhepi, Mjellma ; Andersone, Daina ; Stropuviene, Sigita ; Baranauskaite, Asta ; Hajjaj-Hassouni, Naija ; Benbouazza, Karima ; Allali, Fadoua ; Bahiri, Rachid ; Amine, Bouchra ; Jacobs, Johannes W.G. ; Huisman, Margriet ; Hoekstra, Monique ; Haugeberg, Glenn ; Gjelberg, Hilde ; Sierakowski, Stanislaw ; Majdan, Maria ; Romanowski, Wojciech ; Tlustochowicz, Witold ; Kapolka, Danuta ; Sadkiewicz, Stefan ; Zarowny-Wierzbinska, Danuta ; Ionescu, Ruxandra ; Predeteanu, Denisa ; Karateev, Dmitry ; Luchikhina, Elena ; Chichasova, Natalia ; Badokin, Vladimir ; Skakic, Vlado ; Dimic, Aleksander ; Nedovic, Jovan ; Stankovic, Aleksandra ; Naranjo, Antonio ; Rodríguez-Lozano, Carlos ; Calvo-Alen, Jaime ; Belmonte, Miguel ; Baecklund, Eva ; Henrohn, Dan ; Oding, Rolf ; Liveborn, Margareth ; Holmqvist, Ann-Carin ; Gogus, Feride ; Tunc, Recep ; Celic, Selda ; Badsha, Humeira ; Mofti, Ayman ; Taylor, Peter ; McClinton, Catherine ; Woolf, Anthony ; Chorghade, Ginny ; Choy, Ernest ; Kelly, Stephen ; Pincus, Theodore ; Yazici, Yusuf ; Bergman, Martin ; Craig-Muller, Jurgen ; Kautiainen, Hannu ; Swearingen, Christopher
• Data: 2022
• Identificador Persistente: http://hdl.handle.net/11449/219633
• Origem: Oasisbr
• Assunto(s): Bmi; Disease activity; Gender; Rheumatoid arthritis
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Made available in DSpace on 2022-04-28T18:56:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-01

Objective: To investigate whether body mass index (BMI), as a proxy for body fat, influences rheumatoid arthritis (RA) disease activity in a gender-specific manner. Methods: Consecutive patients with RA were enrolled from 25 countries into the QUEST-RA program between 2005 and 2008. Clinical and demographic data were collected by treating rheumatologists and by patient self-report. Distributions of Disease Activity Scores (DAS28), BMI, age, and disease duration were assessed for each country and for the entire dataset; mean values between genders were compared using Student's t-tests. An association between BMI and DAS28 was investigated using linear regression, adjusting for age, disease duration and country. Results: A total of 5,161 RA patients (4,082 women and 1,079 men) were included in the analyses. Overall, women were younger, had longer disease duration, and higher DAS28 scores than men, but BMI was similar between genders. The mean DAS28 scores increased with increasing BMI from normal to overweight and obese, among women, whereas the opposite trend was observed among men. Regression results showed BMI (continuous or categorical) to be associated with DAS28. Compared to the normal BMI range, being obese was associated with a larger difference in mean DAS28 (0.23, 95% CI: 0.11, 0.34) than being overweight (0.12, 95% CI: 0.03, 0.21); being underweight was not associated with disease activity. These associations were more pronounced among women, and were not explained by any single component of the DAS28. Conclusion: BMI appears to be associated with RA disease activity in women, but not in men. © Copyright Clinical and Experimental Rheumatology 2010.

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University of California Berkeley, Berkeley, CA

North Karelia Central Hospital, Joensuu

Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre

Universidade Federal do Ceará, Fortaleza

Universidade Estadual de São Paulo, São Paulo

Hospital Universitário de Brasília, Brasilia

University of Ioannina Ioannina

Waterford Regional Hospital, Waterford

Connolly Hospital, Dublin

University of Genova, Genova

Rheumatology Department, Pristine

Institute of Experimental and Clinical Medicine Vilnius University, Vilnius

University Medical Centre Utrecht, Utrecht

Jyväskylä Central Hospital, Jyväskylä

Medcare Oy, Äänekoski

Hospital Oakland Research Institute, Oakland, CA

Hospital San Juan Bautista, Catamarca

Hospital of Cordoba, Cordoba

Universidade do Estado do Rio de Janeiro, Rio de Janeiro

Riverside Professional Centre, Sydney, NS

Copenhagen University Hospital at Hvidovre, Hvidovre

King Christian the Xth Hospital, Gråsten

Copenhagen University Hospital at Herlev, Herlev

Al-Azhar University, Cairo

Assiut University Hospital, Assiut

Abo Sohage University Hospital, Sohage

Tartu University Hospital, Tartu

East-Tallinn Central Hospital, Tallinn

Centre for Clinical and Basic Research, Tallinn

Satakunta Central Hospital, Rauma

University René Descartes Hôpital Cochin, Paris

Dijon University Hospital University of Burgundy INSERM U887, Dijon

Hôpital Lapeyronie, Montpellier

Hôpital Hautepierre, Strasbourg

School of Medicine National University of Athens, Athens

Euroclinic Hospital, Athens

Evangelisches Fachkrankenhaus, Ratingen

Schlosspark-Klinik, Berlin

University Medicine Berlin, Berlin

Semmelweis University of Medical Sciences, Budapest

Ilona Újfalussy Polyclinic of the Hospitaller Brothers of St. John of God in Budapest, Budapest

St. Vincent University Hospital, Dublin

Our Lady's Hospice, Dublin

Department of Immunology, Lucknow

Vedanta Institiute of Medical Sciences, Ahmedabad

Department of Immunology Jaipur Hospital

Santa Chiara Hospital, Pisa

Catholic University of Sacred Heart, Rome

University of Ancona, Ancona

Institute of Rheumatology Tokyo Women's Medical University, Tokyo

Department of Rheumatology Kyoto First Red Cross Hospital, Kyoto

Shono Rheumatism Clinic, Fukuoka

Kenyatta Hospital, Nairobi

Pauls Stradina Clinical University Hospital, Riga

Kaunas University Hospital, Kaunas

El Ayachi Hospital Mohamed Vth Souissi University, Rabat

Sint Franciscus Gasthuis Hospital, Rotterdam

Medisch Spectrum Twente, Enschede

Sørlandet Hospital, Kristiansand

Medical University in Bialystok, Bialystok

Medical University of Lublin, Lublin

Poznan Rheumatology Centre in Srem, Srem

Military Institute of Medicine, Warsaw

Silesian Hospital for Rheumatology and Rehabilitation in Ustron Slaski, Ustroñ Slaski

Szpital Wojewodzki im. Jana Biziela, Bydgoszcz

Wojewodzki Zespol Reumatologiczny im. dr Jadwigi Titz-Kosko, Sopot

Spitalul Clinic Sf Maria, Bucharest

Institute of Rheumatology of Russian Academy of Medical Sciences, Moscow

Moscow Medical Academy, Moscow

Russian Medical Academy of Postgraduate Education, Moscow

Rheumatology Institut, Niska Banja

Hospital de Gran Canaria Dr. Negrin, Las Palmas

Hospital Sierrallana Ganzo, Torrelavega

Hospital General de Castellón, Castellón

Uppsala University Hospital, Uppsala

Centrallasarettet, Västerås

Hudiksvall Medical Clinic, Hudiksvall

Gazi University Medical Faculty, Ankara

Meram Medical Faculty, Konya

Cerrahpasa Medic Faculty, Istanbul

Dubai Bone and Joint Centre, Dubai

American Hospital Dubai, Dubai

Charing Cross Hospital, London

Royal Cornwall Hospital, Truro

Kings College Hospital, London

Vanderbilt University, Nashville, TN

NYU Hospital for Joint Diseases, New York, NY

Taylor Hospital, Ridley Park, PA

Centra Care Clinic, St. Cloud, MN

University of Arkansas for Medical Sciences, Little Rock, AR

New York University Hospital for Joint Diseases, New York, NY

Universidade Estadual de São Paulo, São Paulo