Author(s):
Fuchs, Flávio D. ; Fuchs, Sandra C. ; Poli-de-Figueiredo, Carlos E. ; Figueiredo Neto, José A. ; Scala, Luiz César N. ; Vilela-Martin, José F. ; Moreira, Leila B. ; Chaves, Hilton ; Gomes, Marco Mota ; De Sousa, Marcos R. ; E Silva, Ricardo Pereira ; Castro, Iran ; Cesarino, Evandro José ; Sousa, Ana Luiza Lima ; Alves, João Guilherme ; Steffens, André Avelino ; Brandão, Andréa Araujo ; Bortolotto, Luiz Aparecido ; Neto, Abrahão Afiune ; Nóbrega, Antônio C. ; Franco, Roberto Silva [UNESP] ; Filho, Dario C. Sobral ; Nobre, Fernando ; Schlatter, Rosane ; Gus, Miguel ; De David, Caroline Nespolo ; Rafaelli, Leticia ; Sesin, Guilhermo Prates ; Berwanger, Otávio ; Whelton, Paul K.
Date: 2022
Persistent ID: http://hdl.handle.net/11449/221112
Origin: Oasisbr
Subject(s): Chlorthalidone and amiloride; Clinical trials; Hypertension; Optimal blood pressure; Prehypertension
Description
Made available in DSpace on 2022-04-28T19:09:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-04-01
Ministry of Science and Technology
Background: To determine the effectiveness of low-dose diuretic therapy to achieve an optimal level of blood pressure (BP) in adults with prehypertension. Methods: The PREVER-prevention trial was a randomized, parallel, double-blinded, placebo-controlled trial, with 18 months of follow-up, conducted at 21 academic medical centers in Brazil. Of 1772 individuals evaluated for eligibility, 730 volunteers with prehypertension who were aged 30-70 years, and who did not reach optimal blood pressure after 3 months of lifestyle intervention, were randomized to a fixed association of chlorthalidone 12.5mg and amiloride 2.5mg or placebo once a day. The main outcomes were the percentage of participants who achieved an optimal level of BP. Results: A total of 372 participants were randomly allocated to diuretics and 358 to placebo. After 18 months of treatment, optimal BP was noted in 25.6% of the diuretic group and 19.3% in the placebo group (P<0.05). The mean net reduction in SBP and DBP for the diuretic group compared with placebo was 2.8mmHg (95% CI 1.1 to 4.5) and 1.1mmHg (95% CI -0.09 to 2.4), respectively. Most participants in the active treatment group (74.5%) and in the placebo group (80.7%) continued to have BP in the prehypertension range or progressed to hypertension. Conclusion: Low-dose diuretic therapy increased the probability of individuals with prehypertension to achieve optimal BP but most of those treated continued to have a BP in the prehypertension range or progressed to having overt hypertension.
Serviço de Cardiologia Hospital de Clínicas de Porto Alegre Universidade Federal do Rio Grande do Sul, Ramiro Barcelos, 2350
Faculdade deMedicina Hospital São Lucas PUCRS
Hospital Universitário Universidade Federal do Maranhão
Hospital Universitário Júlio Müller Universidade Federal de Mato Grosso
Faculdade de Medicina de São José do Rio Preto Hospital de Base
Universidade Federal de Pernambuco
Hospital do Coração
Hospital das Clínicas da Universidade Federal de Minas Gerais
Hospital Universitário Walter Cantídio Universidade Federal do Ceará
Instituto de Cardiologia
Faculdade de Ciências Farmacêuticas USP Ribeirão Preto
Hospital das Clínicas da Universidade Federal de Goiás
Instituto de Medicina Integral Prof. Fernando Figueira
Universidade Federal de Pelotas
Universidade do Estado do Rio de Janeiro
Instituto do Coração Faculdade deMedicina Universidade de São Paulo
Hospital do Coração Anis Rassi
Hospital Universitário Antônio Pedro Universidade Federal Fluminense
Faculdade de Medicina de Botucatu
Hospital Universitário PROCAPE
Faculdade deMedicina de Ribeirão Preto USP Ribeirão Preto
Department of Epidemiology Tulane University School of Public Health and Tropical Medicine
Research Institute HC or Hospital do Coração
Faculdade de Medicina de Botucatu
