Autor(es): Santos, Caique ; Orcina, Bernardo da Fonseca ; Reia, Verônica Caroline Brito ; Ribeiro, Lucas Gabriel [UNESP] ; Grotto, Rejane M. T. [UNESP] ; Prudenciatti, Aruã [UNESP] ; de Moraes, Leonardo Nazario [UNESP] ; Zangrando, Mariana Ragghianti ; Vilhena, Fabiano Vieira ; Santos, Paulo Sérgio da Silva
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/221913
Origem: Oasisbr
Assunto(s): Coronavirus infections; Dentifrices; In vitro techniques; Mouthwash
Made available in DSpace on 2022-04-28T19:41:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Aim: This research suggested an in vitro virucidal action of a dental gel and a mouthwash with phthalocyanine derivative. Purpose: The aim of this study was to report an in vitro study evaluating the virucidal capacity of mouthwash and dental gel containing anionic phthalocyanine derivate (APD). Methods: The research followed the recommendations of the National Health Surveillance Agency (ANVISA) and adapted methodology, described in the standards EN14776: 2015; ASTM E1053-11 and the Robert Koch Institute – RKI, in addition to good laboratory practices (GLP). The determination of the percentage of inactivation of the SARS-CoV-2 virus particles was carried out by imposing the viral solution in contact with the respective tested products, with intervals of 30 seconds, 1 and 5 minutes, with subsequent submission of the aliquots, recovered in cell culture microplates following virus titration using the TCID50 (50% Median Tissue Culture Infectious Dose). Results: The Mouthwash APD presented 90% of viral inactivation percentage, while the dental gel APD demonstrated 99.99% of viral inactivation. Conclusion: In vitro analyses showed that mouthwash and dental gel APD can reduce the viability of SARS-CoV-2 virus particles.
Bauru School of Dentistry University of São Paulo Periodontics
Bauru School of Dentistry University of São Paulo Department of Surgery Stomatology Pathology and Radiology
Botucatu Medical School São Paulo State University (UNESP)
TRIALS – Oral Health & Technologies
Botucatu Medical School São Paulo State University (UNESP)
