Autor(es):
Pereira, Rodrigo Martins ; da Cruz Rodrigues, Kellen Cristina ; Sant'Ana, Marcella Ramos ; Peruca, Guilherme Francisco ; Anaruma, Chadi Pellegrini [UNESP] ; de Campos, Thaís Dantis Pereira ; dos Santos Canciglieri, Raphael ; de Melo, Diego Gomes ; Simabuco, Fernando Moreira ; da Silva, Adelino Sanchez Ramos ; Cintra, Dennys Esper ; Ropelle, Eduardo Rochete ; Pauli, José Rodrigo ; de Moura, Leandro Pereira
Data: 2022
Identificador Persistente: http://hdl.handle.net/11449/222825
Origem: Oasisbr
Assunto(s): Combined training; Diabetes; Hepatic steatosis; Insulin sensitivity; Liver; Obesity
Descrição
Made available in DSpace on 2022-04-28T19:47:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-15
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Hepatic steatosis is directly associated with hepatic inflammation and insulin resistance, which is correlated with hyperglycemia and type 2 diabetes mellitus (T2DM). Aerobic and strength training have been pointed out as efficient strategies against hepatic steatosis. However, little is known about the effects of the combination of those two protocols on hepatic steatosis. Therefore, this study aimed to evaluate the impact of short-term combined training (STCT) on glucose homeostasis and in the synthesis and oxidation of fat in the liver of obesity-induced mice with hepatic steatosis. Swiss mice were distributed into three groups: control lean (CTL), sedentary obese (OB), and combined training obese (CTO). The CTO group performed the STCT protocol, which consisted of strength and aerobic exercises in the same session. The protocol lasted seven days. The CTO group reduced the glucose levels and fatty liver when compared to the OB group. Interestingly, these results were observed even without reductions in body adiposity. CTO group also showed increased hepatic insulin sensitivity, with lower hepatic glucose production (HGP). STCT reduced the expression of the lipogenic genes Fasn and Scd1 and hepatic inflammation, as well as increased the ACC phosphorylation and the oxidative genes Cpt1a and Ppara, reverting the complications caused by obesity. Since this protocol increased lipid oxidation and reduced hepatic lipogenesis, regardless of body fat mass decrease, it can be considered an effective non-pharmacological strategy for the treatment of hepatic steatosis.
Exercise Cell Biology Lab Faculty of Applied Sciences University of Campinas
Laboratory of Nutritional Genomics Faculty of Applied Sciences University of Campinas
Motricity Sciences Institute of Biosciences São Paulo State University Julio de Mesquita Filho
Multidisciplinary Laboratory of Food and Health Faculty of Applied Sciences University of Campinas
School of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)
Postgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School USP
Laboratory of Molecular Biology of Exercise Faculty of Applied Sciences University of Campinas
Motricity Sciences Institute of Biosciences São Paulo State University Julio de Mesquita Filho
FAPESP: 2015/07199-2
FAPESP: 2016/12569-6
FAPESP: 2016/24406-4
