Author(s):
Chalhoub, Nathalie E. ; Wenderfer, Scott E. ; Levy, Deborah M. ; Rouster-Stevens, Kelly ; Aggarwal, Amita ; Savani, Sonia I. ; Ruth, Natasha M. ; Arkachaisri, Thaschawee ; Qiu, Tingting ; Merritt, Angela ; Onel, Karen ; Goilav, Beatrice ; Khubchandani, Raju P. ; Deng, Jianghong ; Fonseca, Adriana R. ; Ardoin, Stacy P. ; Ciurtin, Coziana ; Kasapcopur, Ozgur ; Jelusic, Marija ; Huber, Adam M. ; Ozen, Seza ; Klein-Gitelman, Marisa S. ; Appenzeller, Simone ; Cavalcanti, André ; Fotis, Lampros ; Lim, Sern Chin ; Silva, Rodrigo M. ; Miramontes, Julia Ramírez- ; Rosenwasser, Natalie L. ; Saad-Magalhaes, Claudia [UNESP] ; Schonenberg-Meinema, Dieneke ; Scott, Christiaan ; Silva, Clovis A. ; Enciso, Sandra ; Terreri, Maria T. ; Torres-Jimenez, Alfonso-Ragnar ; Trachana, Maria ; Al-Mayouf, Sulaiman M. ; Devarajan, Prasad ; Huang, Bin ; Brunner, Hermine I. ; Abulaban, Khalid ; Aguiar, Cassyanne ; Ahn, Sun-Young ; Akoghlanian, Shoghik ; Al-Abrawi, Safiya ; Aljaberi, Najla ; Alperin, Risa ; Angeles-Han, Sheila ; Ardalan, Kaveh ; Bader-Meunier, Brigitte ; Balboni, Imelda ; Barbar-Smiley, Fatima ; Baxter, Sarah ; Beary, John ; Boneparth, Alexis ; Brakeman, Paul ; Bridges, John ; Burgos-Vargas, Ruben ; Cabral, David A. ; Cameto, Juan ; Carter, Caitlin ; Chang, Joyce ; Chédeville, Gaëlle ; Chhakchhuak, Christine ; Chiraseveenuprapund, Peter ; Cifuentes Alvarado, Mayra ; Concannon, Anthony ; Cooper, Jennifer ; Cron, Randy ; De Carvalho, Luciana Martins ; De Quattro, Kimberly ; De Ranieri, Deirdre ; Dizon, Brian ; Donnelly Wrigley, Catherine ; Duong, Minh Dien ; Eberhard, Anne ; Ede, Kaleo ; Edelheit, Barbara ; Edens, Cuoghi ; Espada, Graciela ; Farhey, Yolanda ; Flores, Francisco ; Fritz, Deborah ; Ganguli, Suhas ; Gilbert, Mileka ; Gittar, Patsy ; Greenbaum, Larry ; Grom, Alexei ; Gulati, Gaurav ; Harry, Onengiya ; Hayward, Kristen ; Henrickson, Michael ; Hersh, Aimee ; Hiraki, Linda ; Hiskey, Megan ; Hoffmann, Sarah ; Hollander, Matthew ; Hom, Christine ; Houk, Lawrence ; Houk, J. Brian ; Hsieh, Elena W.Y. ; Hsu, Joyce ; Jensen, Paul ; Joos, Rik ; Jurado, Rosario ; Jusan Fiorot, Fernanda ; Kallash, Mahmoud ; Kamphuis, Sylvia ; Keltsev, Vladimir ; Khanna, Surabhi ; Kim, Susan ; Kimseng, Karen Joy ; Knight, Andrea ; Kunder, Rebecca ; Lai, Jamie ; Laskin, Benjamin ; Lewandowski, Laura ; Lim, Lily ; Linda, Wagner-Weiner ; Lo, Mindy ; Lovell, Daniel ; Luggen, Michael ; Madison, Jacqueline ; Mansuri, Asif ; Martin, Lorena ; Mason, Sherene ; Miller, Michael ; Mina, Rina ; Mohammed, Abdul ; Moncrieffe, Halima ; Moorthy, Lakshmi ; Morgan, Esi ; Mosquera, Angela ; Muntel, Emily ; Muscal, Eyal ; Myones, Barry ; Nocton, James ; Ogbu, Ekemini ; Okamura, Daryl ; Olson, Judyann ; Orrock, Janet ; Paim-Marques, Luciana ; Pain, Clare ; Park, Catherine ; Patel, Pooja ; Pereira, Maria ; Prado, Rogerio do ; Radhakrishna, Suhas ; Rheault, Michelle ; Ridgway, William ; Riskalla, Mona ; Ronis, Tova ; Sadun, Rebecca ; Sagcal-Gironella, Anna Carmela ; Santos, Maria carolina ; Schikler, Kenneth ; AL Suwairi, Wafaa ; Siddiqi, Nabeela ; Silva, Marco Felipe ; Singh-Grewal, Davinder ; Smitherman, Emily ; Smolewska, Elzbieta ; Son, Mary Beth ; Srinivasalu, Hemalatha ; Sule, Sangeeta ; Susic, Gordana ; Syed, Reema ; Thatayatikom, Akaluck ; Ting, Tracy ; Toth, Mary ; Turnier, Jessica ; Vashisht, Priyanka ; Vega Fernandez, Patricia ; Velasquez, Monica ; von Scheven, Emily ; Wahezi, Dawn ; Ware, Avis ; Wu, Eveline ; Yan, Jacqueline ; Yildirim-Toruner, Cagri ; Zamparo, Celso ; Zhang, Yujuan ; Lawson, Erica
Date: 2022
Persistent ID: http://hdl.handle.net/11449/223171
Origin: Oasisbr
Description
Made available in DSpace on 2022-04-28T19:49:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01
Arthritis Foundation
Institute of Clinical and Translational Sciences
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institute of Diabetes and Digestive and Kidney Diseases
National Center for Advancing Translational Sciences
Objective: To develop a standardized steroid dosing regimen (SSR) for physicians treating childhood-onset systemic lupus erythematosus (SLE) complicated by lupus nephritis (LN), using consensus formation methodology. Methods: Parameters influencing corticosteroid (CS) dosing were identified (step 1). Data from children with proliferative LN were used to generate patient profiles (step 2). Physicians rated changes in renal and extrarenal childhood-onset SLE activity between 2 consecutive visits and proposed CS dosing (step 3). The SSR was developed using patient profile ratings (step 4), with refinements achieved in a physician focus group (step 5). A second type of patient profile describing the course of childhood-onset SLE for ≥4 months since kidney biopsy was rated to validate the SSR-recommended oral and intravenous (IV) CS dosages (step 6). Patient profile adjudication was based on majority ratings for both renal and extrarenal disease courses, and consensus level was set at 80%. Results: Degree of proteinuria, estimated glomerular filtration rate, changes in renal and extrarenal disease activity, and time since kidney biopsy influenced CS dosing (steps 1 and 2). Considering these parameters in 5,056 patient profile ratings from 103 raters, and renal and extrarenal course definitions, CS dosing rules of the SSR were developed (steps 3–5). Validation of the SSR for up to 6 months post–kidney biopsy was achieved with 1,838 patient profile ratings from 60 raters who achieved consensus for oral and IV CS dosage in accordance with the SSR (step 6). Conclusion: The SSR represents an international consensus on CS dosing for use in patients with childhood-onset SLE and proliferative LN. The SSR is anticipated to be used for clinical care and to standardize CS dosage during clinical trials.
University of Cincinnati College of Medicine
Baylor College of Medicine
The Hospital for Sick Children and The University of Toronto
Emory University and Children's Healthcare of Atlanta
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Medical University of South Carolina
KK Women's and Children's Hospital
Cincinnati Children's Hospital Medical Center
Hospital for Special Surgery
Albert Einstein College of Medicine
SRCC Children's Hospital
Capital Medical University and National Center for Children's Health
Universidade Federal do Rio de Janeiro
Nationwide Children's Hospital
University College London
Cerrahpasa Medical School Istanbul University-Cerrahpasa
University of Zagreb School of Medicine
IWK Health Centre and Dalhousie University
Hacettepe University
Northwestern University Feinberg School of Medicine and Ann & Robert H. Lurie Children's Hospital of Chicago
University of Campinas
Hospital das Clínicas da Universidade Federal de Pernambuco
National and Kapodistian University of Athens
University Teknologi MARA
Instituto Mexicano del Seguro Social
University of Washington and Seattle Children's Hospital
São Paulo State University
Amsterdam University Medical Center
Red Cross War Memorial Children's Hospital and University of Cape Town
Universidade de São Paulo
Hospital de la Beneficencia Española
Universidade Federal de São Paulo
National Medical Center La Raza
Aristotle University of Thessaloniki
King Faisal Specialist Hospital and Research Center and Alfaisal University
University of Cincinnati College of Medicine and Cincinnati Children's Hospital Medical Center
São Paulo State University
CNPq: 303422/2015-7
FAPESP: FAPESP 2015/03756-4
National Institute of Arthritis and Musculoskeletal and Skin Diseases: P30-AR-076316
National Institute of Diabetes and Digestive and Kidney Diseases: P50-DK-096418
National Institute of Arthritis and Musculoskeletal and Skin Diseases: R34-AR-071651
National Center for Advancing Translational Sciences: T32-AR-050958
