Occurrence of pneumocystis pneumonia in HIV-infected patients and the interference of the highly active antiretroviral therapy

• Autor(es): Barbosa, Alexandre Naime [UNESP] ; Souza, L. R. [UNESP]
• Data: 2022
• Identificador Persistente: http://hdl.handle.net/11449/225100
• Origem: Oasisbr
• Assunto(s): AIDS; Antiretroviral treatment; Pneumocystis pneumonia; T CD4 + lymphocytes
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Made available in DSpace on 2022-04-28T20:39:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-01

From the beginning of the AIDS epidemic, pneumocystis pneumonia (PCP) has been distinguished as one of the most frequent opportunistic diseases with high morbid-mortality. As from 1996, the advent of the highly active antiretroviral therapy (HAART) has changed the characteristics of such epidemic by reducing its related diseases and, as a result, AIDS-related mortality. With the purpose to estimate PCP occurrence and HAART interference, 376 HIV-infected or AIDS patients were studied from January 1992 to December 2002. Among them, 58 (15.5%) PCP cases were found. There was a higher occurrence of PCP in the group of patients in which HAART was not used, with 40 (69.0%) of the episodes. As regards the studied period, a tendency to a linear reduction in annual PCP incidence was observed. The mean of T CD4+ lymphocytes in the patients with PCP (117 cells/mm3) was significantly lower when compared to that of the other individuals (325 cells/mm3). Therefore, this study suggests a temporal reduction in PCP occurrence related to HAART use with higher T CD4+ lymphocyte counts. Nevertheless, this opportunistic infection still shows significant incidence in AIDS patients. (NCT00516581).

Department of Tropical Diseases and Imaging Diagnosis Botucatu Medical School São Paulo State University - UNESP, Botucatu, São Paulo State

Departamento de Doenças Tropicais e Diagnóstico Por Imagem Faculdade de Medicina de Botucatu - UNESP, 18618-970, Botucatu, SP

Department of Tropical Diseases and Imaging Diagnosis Botucatu Medical School São Paulo State University - UNESP, Botucatu, São Paulo State

Departamento de Doenças Tropicais e Diagnóstico Por Imagem Faculdade de Medicina de Botucatu - UNESP, 18618-970, Botucatu, SP