Author(s): Chehoud, Keila Aziz [UNESP] ; Chiba, Fernando Yamamoto [UNESP] ; Sassaki, Kikue Takebayashi [UNESP] ; Garbin, Cléa Adas Saliba [UNESP] ; Sumida, Doris Hissako [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/225400
Origin: Oasisbr
Subject(s): Insulin receptor substrate; Insulin sensitivity; Insulin signal; Plasma fluoride; Rats and insulin
Made available in DSpace on 2022-04-28T20:48:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-10-01
Forty seven-week-old male castrated Wistar rats were randomly divided evenly into a control group and a fluoride (F) group. The latter was given a single dose of NaF from a solution containing 1.0 mg F ion/kg bw, administered by gavage. After 30 min, the following experiments were performed: intravenous insulin tolerance test (0.75 U/kg bw) and determination of the insulin receptor substrate (pp 185-IRS-1/IRS/2) tyrosine phosphorylation status. The acute treatment with NaF promoted increased blood glycemia, but there were no significant changes in the insulin sensitivity and in the pp185 tyrosine phosphorylation status in the muscular or in the white adipose tissues. Copyright © 2008 The International Society for Fluoride Research Inc.
Department of Basic Sciences Dental School of Araçatuba São Paulo State University - UNESP, Araçatuba
Department of Child and Social Dentistry Dental School of Araçatuba São Paulo State University - UNESP, Araçatuba
Dental School of Araçatuba São Paulo State University - UNESP, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SP
Department of Basic Sciences Dental School of Araçatuba São Paulo State University - UNESP, Araçatuba
Department of Child and Social Dentistry Dental School of Araçatuba São Paulo State University - UNESP, Araçatuba
Dental School of Araçatuba São Paulo State University - UNESP, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SP
