Author(s): Marinho, Márcia [UNESP] ; Oliveira-Júnior, Itamar Souza [UNESP] ; Monteiro, Cristina Maria Rodrigues [UNESP] ; Perri, Silvia Helena [UNESP] ; Salomão, Reinaldo [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/225482
Origin: Oasisbr
Made available in DSpace on 2022-04-28T20:52:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-01-01
Our aim was to evaluate the pulmonary changes induced by Leptospira interrogans infection in hamsters, and the gene expression of endogenous mediators in lung fragments during 28 days of observation. The animals were euthanized on days 4, 7, 14, 21, and 28 post-inoculation. Histopathologic lung analysis showed hemorrhage, pneumonia, alveolar congestion, and infiltrated cellular areas, with increasing severity until day 21 post-inoculation. Tumor necrosis factor (TNF)-α mRNA expression enhanced in first days with peak on day 4 and slightly decreased in the final phase. The interleukin (IL)-10 remained relatively constant throughout the period, with the exceptions of days 4 and 14. The endothelial nitric-oxide synthesis (eNOS) showed an increased expression on day 4, followed by an augment on days 7 and 14, and remaining constant up to day 28 post-infection. Our results demonstrate that inoculation of L. interrogans sorovar Icterohaemorrhagiae induced pulmonary lesions, including pulmonary hemorrhage, supporting that the lung is a target organ. Copyright © 2009 by The American Society of Tropical Medicine and Hygiene.
Department of Animal Health and Production Microbiology Laboratory FOA Unesp-Estadual Paulista University, Araçatuba, São Paulo
Inflammatory Mediators Laboratory Geriatrics and Gerontology Division Federal University of São Paulo
Infectious Diseases Division Federal University of São Paulo
Universidade Estadual Paulista-Unesp-FOA-Medicina Veterinária- Campus de Araçatuba, Rua Clóvis Pestana, 793, CEP: 16050-680, Araçatuba, São Paulo
Microbiology Laboratory Estadual Paulista University Unesp-FOA-Campus Aracatuba, Rua Clóvis Pestana, 793, CEP: 16050-680, Araçatuba, São Paulo
Inflammatory Mediators Laboratory Geriatrics and Gerontology Division Federal University, São Paulo
Department of Animal Health and Production Estadual Paulista University Unesp-FOA-Campus de Araçatuba, São Paulo
Department of Animal Health and Production Estadual Paulista University Unesp-FOA-Campus Araçatuba, São Paulo
Infectious Diseases Division Federal University, São Paulo
Department of Animal Health and Production Microbiology Laboratory FOA Unesp-Estadual Paulista University, Araçatuba, São Paulo
Universidade Estadual Paulista-Unesp-FOA-Medicina Veterinária- Campus de Araçatuba, Rua Clóvis Pestana, 793, CEP: 16050-680, Araçatuba, São Paulo
Microbiology Laboratory Estadual Paulista University Unesp-FOA-Campus Aracatuba, Rua Clóvis Pestana, 793, CEP: 16050-680, Araçatuba, São Paulo
Department of Animal Health and Production Estadual Paulista University Unesp-FOA-Campus de Araçatuba, São Paulo
Department of Animal Health and Production Estadual Paulista University Unesp-FOA-Campus Araçatuba, São Paulo
