Author(s): Chiba, Fernando Yamamoto [UNESP] ; Colombo, Natália Helena [UNESP] ; Shirakashi, Daisy Jaqueline [UNESP] ; Gomes, Wendrew Douglas De Souza [UNESP] ; Moimaz, Suzely Adas Saliba [UNESP] ; Garbin, Cléa Adas Saliba [UNESP] ; Silva, Cristina Antoniali [UNESP] ; Sumida, Doris Hissako [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/226126
Origin: Oasisbr
Subject(s): Fluoride; Insulin receptor substrate; Insulin sensitivity; Insulin signal; Rats and insulin
Made available in DSpace on 2022-04-28T21:25:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01
With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. Copyright © 2010 The International Society for Fluoride Research Inc.
Dental School of Araçatuba UNESP - Univ Estadual Paulista, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SP
Department of Child and Social Dentistry Dental School of Araçatuba UNESP - Univ Estadual Paulista
Dental School of Araçatuba UNESP - Univ Estadual Paulista, R. José Bonifácio, 1193, CEP: 16015-050, Araçatuba-SP
Department of Child and Social Dentistry Dental School of Araçatuba UNESP - Univ Estadual Paulista
