Author(s): Cespedes, Graziely Ferreira [UNESP] ; Vicente, Eduardo Festozo [UNESP] ; Cilli, Eduardo Maffud [UNESP] ; Jubilut, Guita Nicolaewsky ; Nakaie, Clovis Ryuichi
Date: 2022
Persistent ID: http://hdl.handle.net/11449/226338
Origin: Oasisbr
Subject(s): FTIR; Resin; SPPS
Made available in DSpace on 2022-04-28T22:37:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-06-06
Despite the increase in peptide chain aggregation, which decreases the rate of coupling reactions, the synthesis and use of very highly substituted resins still remains as a controversial point in the SPPS, due to its clear economical advantages (lesser solvent consumption and higher amount of peptide per synthesis). In order to better investigate the synthesis and the use of very highly substituted resins, the FTIR, NMR and EPR were compared. By FTIR techniques it was possible to follow all the steps of resin synthesis and the factors affecting the aggregation of the chains inside the peptidil-BHAR and MBHAR.
Departamento de Bioquímica e Tecnologia Química Instituto de Química Universidade Estadual Paulista, R. Francisco Degni, s/n, 14800-900 Araraquara- SP
Departamento de Biofísica Universidade Federal de São Paulo, R. Três de Maio, 100, 04004-020 São Paulo- SP
Departamento de Bioquímica e Tecnologia Química Instituto de Química Universidade Estadual Paulista, R. Francisco Degni, s/n, 14800-900 Araraquara- SP
