Author(s): de Azevedo, Vera Lucia Fernandes [UNESP] ; Santos, Paulo Sergio Santana [UNESP] ; de Oliveira, Gildàsio Silveira ; Módolo, Gabriel Pinheiro ; Domingues, Maria Aparecida Custódio [UNESP] ; Castiglia, Yara Marcondes Machado ; Vianna, Pedro Thadeu Galvão ; Vane, Luiz Antonio [UNESP] ; Módolo, Norma Sueli Pinheiro [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/227113
Origin: Oasisbr
Subject(s): Acute kidney injury; Colloids; Fluid therapy; Hetastarch; Rats
Made available in DSpace on 2022-04-29T06:48:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-01
PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1 or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.
Postgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
Department of Anesthesiology Northwestern University Feinberg School of Medicine, Chicago, IL
Santa Casa Faculty of Medicine, Sao Paulo
Department of Pathology Botucatu Medical School, UNESP, Sao Paulo
Department of Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
Postgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
Department of Pathology Botucatu Medical School, UNESP, Sao Paulo
Department of Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
