Author(s): Kurokawa, Cilmery Suemi [UNESP] ; Hashimoto, Miriam [UNESP] ; Rugolo, Ligia Maria Suppo de Souza [UNESP] ; Bentlin, Maria Regina [UNESP] ; Golin, Marjorie de Assis [UNESP] ; Peraçoli, José Carlos [UNESP] ; da Silva, Marcia Guimarães [UNESP] ; Corrente, José Eduardo [UNESP] ; Fekete, Saskia Maria Wiegerinck [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/227532
Origin: Oasisbr
Subject(s): Cytokine; Early infection; In vivo inflammation; Infant; Innate immunity; Premature
Made available in DSpace on 2022-04-29T07:13:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-12-01
This study aimed to evaluate the levels of pro- and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups as focal EOI (n=19) and non-infected (n=27). Interleukin (IL)-6 and IL-8 levels were higher, whereas IL-10 and IL-12 p70 levels were lower in the EOI when compared to the non-infected group. The best combination of cytokines was IL-6+IL-8, with a diagnostic accuracy of 0.97. Focal EOI after PPROM is associated with increased levels of IL-6 and IL-8 and diminished IL-10 and IL-12 in the cord blood of preterm infants. Combined assessment of IL-6 and IL-8 in cord blood may provide an additional tool for identifying preterm infants who develop EOI after PPROM.
Department of Pediatrics Botucatu Medical School UNESP, Botucatu, São Paulo
Blood Center Botucatu Medical School UNESP, Botucatu, São Paulo
Department of Gynaecology and Obstetrics Botucatu Medical School UNESP, Botucatu, São Paulo
Department of Pathology Botucatu Medical School UNESP, Botucatu, São Paulo
Biostatistics Department Bioscience Institute of Botucatu UNESP, Botucatu, São Paulo
Department of Pediatrics Botucatu Medical School UNESP, Botucatu, São Paulo
Blood Center Botucatu Medical School UNESP, Botucatu, São Paulo
Department of Gynaecology and Obstetrics Botucatu Medical School UNESP, Botucatu, São Paulo
Department of Pathology Botucatu Medical School UNESP, Botucatu, São Paulo
Biostatistics Department Bioscience Institute of Botucatu UNESP, Botucatu, São Paulo
