Author(s): Sousa, Paula ; Ministro, Paula ; Armuzzi, Alessandro ; Dignass, Axel ; Høivik, Marte Lie ; Barreiro-de Acosta, Manuel ; Vavricka, Stephan ; Saad-Hossne, Rogério [UNESP] ; Gustavo Kotze, Paulo ; Peyrin-Biroulet, Laurent ; Magro, Fernando
Date: 2022
Persistent ID: http://hdl.handle.net/11449/229052
Origin: Oasisbr
Subject(s): Crohn's disease; Inflammatory bowel disease; Precision medicine; Thiopurines; Ulcerative colitis
Made available in DSpace on 2022-04-29T08:30:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01
Background and aims: The role of thiopurines in therapeutic algorithms of Crohn's disease (CD) and Ulcerative colitis (UC) is being questioned. This work aimed to investigate current practice and future perspectives of Inflammatory Bowel Disease (IBD) physicians regarding the efficacy, safety, and role of precision medicine with thiopurines in IBD. Methods: A 29-questions web-based survey was developed and distributed to IBD physicians worldwide. Results: We collected the complete answers of 408 physicians from 50 countries. Most participants were experienced physicians in IBD; 26.0% met our definition of “IBD expert”. Four physicians reported to not use thiopurines in clinical practice. Most respondents used thiopurines in monotherapy and in combination therapy, both in CD and UC. Respondents tended to consider thiopurines as drugs with a good safety profile, with the agreement of 61.5% of the overall cohort. A minority of physicians (~6%) considered that thiopurines will not be used in the future in IBD patients, while 57.8% believed that these drugs will still be used, in mono and combination therapy. Conclusion: Despite the many emerging treatments in IBD, according to the beliefs of most physicians surveyed, thiopurines will still be an important part of the treatment algorithm of both CD and UC.
Department of Gastroenterology Viseu Unit Tondela-Viseu Hospital Centre
IBD Center Fondazione Policlinico Universitario A. Gemelli IRCCS Universita Cattolica
Department of Medicine I Agaplesion Markus Hospital Goethe-University
Department of Gastroenterology Oslo University Hospital
IBD Unit Department of Gastroenterology Hospital Clínico Universitario de Santiago de Compostela
Division of Gastroenterology and Hepatology University Hospital
Department of Internal Medicine São Paulo State University (Unesp) Medical School
Colorectal Surgery Unit IBD outpatient clinics Catholic University of Paraná (PUCPR)
Department of Gastroenterology and Inserm NGERE U1256 University Hospital of Nancy University of Lorraine
Department of Biomedicine Unit of Pharmacology and Therapeutics University of Porto
Department of Gastroenterology São João University Hospital
MedInUP Centre for Drug Discovery and Innovative Medicines
Department of Internal Medicine São Paulo State University (Unesp) Medical School
