Author(s):
De Carvalho, Flavia Giolo ; Brandao, Camila Fernanda Cunha ; Muñoz, Vitor Rosetto ; Batitucci, Gabriela [UNESP] ; Tavares, Maria Eduarda de Almeida [UNESP] ; Teixeira, Giovana Rampazzo [UNESP] ; Pauli, José Rodrigo ; De Moura, Leandro Pereira ; Ropelle, Eduardo Rochete ; Cintra, Dennys Esper ; da Silva, Adelino Sanchez Ramos ; Junqueira‐Franco, Márcia Varella Morandi ; Marchini, Julio Sergio ; De Freitas, Ellen Cristini [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/229134
Origin: Oasisbr
Subject(s): Adipocyte plasticity; Adipose tissue; Inflammation; Obesity; Taurine
Description
Made available in DSpace on 2022-04-29T08:30:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1β gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019.
School of Physical Education and Sport of Ribeirão Preto University of São Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre
Internal Medicine Department Ribeirão Preto Medical School University of São Paulo-FMRP USP
State University of Minas Gerais - UEMG, Divinopolis unit
Laboratory of Molecular Biology of Exercise University of Campinas-FCA UNICAMP
Department of Food and Nutrition School of Pharmaceutical Sciences of Araraquara São Paulo State University-FCFAR UNESP
Department of Physical Education School of Technology and Science São Paulo State University-UNESP
Laboratory of Nutritional Genomics University of Campinas-FCA UNICAMP
Department of Food and Nutrition School of Pharmaceutical Sciences of Araraquara São Paulo State University-FCFAR UNESP
Department of Physical Education School of Technology and Science São Paulo State University-UNESP
FAPESP: 2017/08036-5
FAPESP: 2017/10080-2
