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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Background: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. Methods: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis. Results: Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062). Conclusion: Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.
Undergrad uate Medical Student. Universidade Federal de Minas Gerais. Avenida Professor Alfredo Balena 190
Endocrinology Unit Department of Internal Medicine Faculdade de Medicina da Universidade Federal de Minas Gerais. Avenida Professor Alfredo Balena 190
Professor and Physician. Internal Medicine Department Universidade Federal do Rio Grande do Sul. Coordinator of the Institute for Health Technology Assessment (IATS/CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507
Physician. Hospital Unimed-BH, Av do Contorno, 3097
Hospitais da Rede Mater Dei
Internal Medicine Resident. Hospital Risoleta Tolentino Neves. Rua das Gabirobas 01
Physician. Hospital Santa Rosália
Hospital João XXIII. Av. Professor Alfredo Balena 400
Physician. Hospital das Clínicas da Faculdade de Medicina de Botucatu
Hospital de Clínicas de Porto Alegre, Av. Ramiro Barcellos, 2350
Hospital Mãe de Deus
Hospital Santo Antônio
Pharmaceutical. Hospital de Clínicas de Porto Alegre, Av. Ramiro Barcellos, 2350
Coordinator of the Research Sector of Grupo Hospitalar Conceição. Professor of the Graduation Program on Evaluation and Production of Technologies for the Brazilian National Health System Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326
Hospital SOS Cárdio
Professor and Infectious Diseases Physician. Internal Medicine Department University Hospital Universidade Federal de Minas Gerais, Av. Prof Alfredo Balena, 110
Nephrologist. Hospital Universitário Ciências Médicas
Hospital Márcio Cunha
Hospital Regional do Oeste, Santa Catarina
PhD Departamento de Pneumologia Faculdade de Medicina Universidade Católica do Rio Grande do Sul (RGS) Porto Alegre Brasil. Hospital São Lucas PUCRS
PhD. Hospital Mãe de Deus Hospital Universitário de Canoas Universidade Federal do Rio Grande do Sul e Instituto de Avaliação de Tecnologia em Saúde (IATS/CNPQ)
Undergraduate Medical Student. Universidade Federal dos Vales do Jequitinhonha e Mucuri. R. Cruzeiro 1
Hospital Luxemburgo
Hospital Nossa Senhora da Conceição, Av. Francisco Trein, 326
Hospital Bruno Born, Av. Benjamin Constant, 881
Hospital Moinhos de Vento, Rio Grande do Sul
Hospital Metropolitano Odilon Behrens
Hospital Santa Cruz
Hospital Julia Kubitschek. Avenida Professor Alfredo Balena 190
Hospital São Lucas PUCRS
Physician. Hospital Eduardo de Menezes. R. Dr. Cristiano Rezende 2213
Physician. Hospital Metropolitano Doutor Célio de Castro. Rua Dona Luiza 311
Hospital São João de Deus
Hospital Semper. Alameda Ezequiel Dias 389
Hospital Universitário Canoas, Rio Grande do Sul
Hospital Universitário de Santa Maria, Rio Grande do Sul
Hospital Tacchini
Associate Professor and Statistician Department of Statistics Universidade Federal de Minas Gerais. Av. Presidente Antônio Carlos, 6627, ICEx, sala 4071
Associate Professor and Internal Medicine Physician. Department of Internal Medicine Medical School; and Telehealth Center University Hospital Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena 190 sala 246
Researcher. Institute for Health Technology Assessment (IATS/ CNPq). Rua Ramiro Barcelos, 2359. Prédio 21 | Sala 507
Physician. Hospital das Clínicas da Faculdade de Medicina de Botucatu
