Author(s):
Pandini, Fabricio Egidio ; Miyauchi Kubo, Fabíola Mayumi ; De Guzzi Plepis, Ana Maria ; Da Conceição Amaro Martins, Virginia ; Da Cunha, Marcelo Rodrigues ; Silva, Vinicius Rodrigues ; Hirota, Vinicius Barroso ; Lopes, Everton ; Menezes, Marcos Antonio ; Pelegrine, André Antonio ; De Andrade, Tiago Negrão ; Iatecola, Amilton ; Da Cruz Britto, Bruna ; Ramos Fernandes, Victor Augusto ; Orsi Gameiro, Luis Felipe ; Correia, Ronny Rodrigues [UNESP] ; Teixeira, Marcelo Lucchesi ; Júnior, Getúlio Duarte ; Bertoni Reis, Carlos Henrique ; De Souza Bastos Mazuqueli Pereira, Eliana ; Buchaim, Daniela Vieira ; Pomini, Karina Torres ; De Bortoli Teixeira, Daniel ; Buchaim, Rogerio Leone ; Lourenço, Edmir Américo
Date: 2022
Persistent ID: http://hdl.handle.net/11449/231591
Origin: Oasisbr
Subject(s): Alcohol intake; Bone regeneration; Bone repair; Chitosan; Collagen; Elastin; Scaffolds
Description
Made available in DSpace on 2022-04-29T08:46:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01
The aim of the present study was to evaluate the use of collagen, elastin, or chitosan biomaterial for bone reconstruction in rats submitted or not to experimental alcoholism. Wistar male rats were divided into eight groups, submitted to chronic alcohol ingestion (G5 to G8) or not (G1 to G4). Nasal bone defects were filled with clot in animals of G1 and G5 and with collagen, elastin, and chitosan grafts in G2/G6, G3/G7, and G4/G8, respectively. Six weeks after, all specimens underwent radiographic, tomographic, and microscopic evaluations. Bone mineral density was lower in the defect area in alcoholic animals compared to the abstainer animals. Bone neoformation was greater in the abstainer groups receiving the elastin membrane and in abstainer and alcoholic rats receiving the chitosan membrane (15.78 ± 1.19, 27.81 ± 0.91, 47.29 ± 0.97, 42.69 ± 1.52, 13.81 ± 1.60, 18.59 ± 1.37, 16.54 ± 0.89, and 37.06 ± 1.17 in G1 to G8, respectively). In conclusion, osteogenesis and bone density were more expressive after the application of the elastin matrix in abstainer animals and of the chitosan matrix in both abstainer and alcoholic animals. Chronic alcohol ingestion resulted in lower bone formation and greater formation of fibrous connective tissue.
Department of Surgery (Otorhinolaryngology) Jundiaí Medical School
Department of Implant Dentistry Faculdade São Leopoldo Mandic
Interunit Postgraduate Program in Bioengineering (EESC/FMRP/IQSC) University of São Paulo (USP)
São Carlos Institute of Chemistry University of São Paulo (USP)
Department of Morphology and Pathology Jundiaí Medical School
Coordination of the Physical Education Course University Center of the Americas (FAM)
Padre Anchieta University Center
Unimetrocamp University Center
Botucatu Medical School (FMB) São Paulo State University (UNESP—Univ Estadual Paulista)
Prosthodontics Department Faculdade São Leopoldo Mandic
Unimar Beneficent Hospital (HBU) University of Marilia (UNIMAR)
Department of Biological Sciences Bauru School of Dentistry (FOB/USP) University of São Paulo
Postgraduate Program in Structural and Functional Interactions in Rehabilitation Postgraduate Department University of Marilia (UNIMAR)
Teaching and Research Coordination of the Medical School University Center of Adamantina (UniFAI)
Postgraduate Program in Animal Health Production and Environment University of Marilia (UNIMAR)
Graduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of São Paulo (FMVZ/USP)
Botucatu Medical School (FMB) São Paulo State University (UNESP—Univ Estadual Paulista)
