Author(s): Nasser, Ana Lucia Martiniano [UNESP] ; Pavan, Fernando Rogério [UNESP] ; Boralle, Nivaldo [UNESP] ; Zocolo, Guilherme Julião [UNESP] ; Dos Santos, Lourdes Campaner [UNESP] ; de Marchi, Mary Rosa Rodrigues [UNESP] ; Leite, Clarice Queico Fujimura [UNESP] ; Vilegas, Wagner [UNESP]
Date: 2022
Persistent ID: http://hdl.handle.net/11449/232273
Origin: Oasisbr
Subject(s): Anti-mycobacterium tuberculosis activity; Qualea species; Triterpenes
Made available in DSpace on 2022-04-29T09:35:28Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-01
The chloroform extract of bark of the tropical tree Qualea parviflora (Vochysiaceae) was fractionated by column chromatography on silica gel, yielding triterpenes (lupeol, lupenone, betulin, epi-betulinic acid and friedelin) and a steroid (β-sitosterol). β-sitosterol, lupenone and lupeol were also identified in Q. grandiflora and Q. multiflora, while friedelin was detected only in Q. Multiflora, by means of gas chromatography-mass spectrometry. The anti-Mycobacterium tuberculosis activity of the chloroform extract and isolated compounds was assayed by MABA and MIC values ranged from 250.0 to 31.2 μg/mL. This study is the first to investigate the chemistry and antitubercular activity of apolar compounds from Qualea species.
Instituto de Química, UNESP, Araraquara, São Paulo
UNESP, Araraquara, São Paulo
Instituto de Química, UNESP, Araraquara, São Paulo
UNESP, Araraquara, São Paulo
