Brazilian network for gestational trophoblastic disease study group consensus on management of gestational trophoblastic disease

• Author(s): Braga, Antonio [UNESP] ; de Souza, Priscila Oliveira [UNESP] ; dos Santos Esteves, Ana Paula Vieira [UNESP] ; Padrón, Lilian [UNESP] ; Uberti, Elza [UNESP] ; Viggiano, Maurícío [UNESP] ; Sun, Sue Yazaki [UNESP] ; Maestá, Izildinha [UNESP] ; Elias, Kevin M. [UNESP] ; Horowitz, Neil [UNESP] ; Berkowitz, Ross [UNESP] ; Grillo, Bruno ; Botogoski, Sheldon Rodrigo ; Madi, José Mauro ; Cardoso, Rodrigo Bernardes ; Costa, Fabiana Rebelo Pereira ; Filho, Antonio Chambo ; Filho, Henrique Zacharias Borges ; Osanan, Gabriel Costa ; Gomes, Daniela Angerame Yela ; Lin, Lawrence Hsu ; Pitorri, Alexandre ; Silveira, Eduardo ; de Andrade, Jurandyr Moreira ; de Sousa, Christiani Bisinoto ; Fernandes, Karayna Gil ; Rezende-Filho, Jorge ; Junior, Joffre Amim ; Cardoso, Fernanda Freitas Oliveira ; Asmar, Flávia Tarabini Castellani ; Pesce, Rodrigo Rocco Pires ; Moraes, Valéria ; Obeica, Bruna ; Mora, Paulo ; Gonçalves, Valéria Cristina ; Itaborahy, Rejane Martins Ribeiro ; Resende, Suely de Souza ; dos Santos Júnior, José Arimatéa ; Costa, Aurélio ; Melo, Elias ; Paiva, Cláudio Sérgio Medeiros ; Silva, Manoel Calheiros ; de Melo, Maria do Carmo Lopes ; Martins, Marília da Glória ; Menezes, Marina de Pádua Nogueira ; Costa, Olívia Lúcia Nunes ; de Amorim, Melania Maria Ramos ; e Silva, João Marcos de Meneses ; de Moraes, Fabio Roberto Ruiz ; Brum, Ione Rodrigues ; de Macedo Lins, Cynthia Dantas ; da Luz, Maríla Gabriela Queiroz ; da Silva, Nirce Carvalho ; Silva, Rita de Cássia Alves Ferreira ; Leal, Elaine Azevedo Soares
• Date: 2022
• Persistent ID: http://hdl.handle.net/11449/232748
• Origin: Oasisbr
• Subject(s): Brazil; Gestational trophoblastic disease; Hydatidiform mole; Rare cancers
• Document Type: Journal article
• Language: English

Description

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OBJECTIVE: To present the Brazilian Network for Gestational Trophoblastic Disease Study Group consensus on management of gestational trophoblastic disease (GTD). STUDY DESIGN: The modified Delphi technique was used in this study to obtain a consensus among Brazilian specialists on the treatment of GTD. For the 64 statements listed, each participant was asked to assign a Likert scale value according to their agreement. The RAND/UCLA method was used to define the level of consensus among the specialists. RESULTS: The response rate of the potential study participants after the 2 rounds was 40/47 (85%). Of the 64 statements presented, there was an agreement on 54/64 (84%). The situations of disagreement were as follows: 1/12 (8%) statements in the section on diagnosis of GTD, 5/10 (50%) statements in the section on treatment of hydatidiform mole (HM), 2/16 (12.5%) statements in the section on diagnosis of gestational trophoblastic neoplasia (GTN), 1/14 (7%) statements in the section on treatment and followup of GTN, and 1/5 (20%) statements in the section on appropriate time to allow pregnancy after HM and GTN. CONCLUSION: This guideline will serve to standardize the conduct among the Brazilian GTD reference centers as well as to guide the new specialized services that may arise and eventually to physicians who may need to treat cases of GTD.

Rio de Janeiro Trophoblastic Disease Center Fluminense Federal University

Porto Alegre Trophoblastic Disease Center Mario Totta Maternity Ward Irmandade da Santa Casa de Misericordia Hospital

Goiania Trophoblastic Disease Center Clinics Hospital of Faculty of Medicine Goias Federal University

Sao Paulo Trophoblastic Disease Center Sao Paulo Hospital Paulista School of Medicine Sao Paulo Federal University

Botucatu Trophoblastic Disease Center Clinics Hospital of Botucatu Medical School Sao Paulo State University

New England Trophoblastic Disease Center Department of Obstetrics and Gynecology Division of Gynecologic Oncology Brigham and Women’s Hospital Dana Farber Cancer Institute/Harvard Cancer Center Harvard Medical School

Clinics Hospital of Parana Federal University

General Hospital of Caxias do Sul University

Carmela Dutra Maternity

Santa Casa Misericordia de Vitoria

Clinics Hospital of Espirito Santo Federal University

Clinics Hospital of Minas Gerais Federal University

Campinas University

Clinics Hospital of Sao Paulo University

Maternity School of Dr Mario de Moraes Altenfelder Silva (Vila Nova Cachoeirinha)

Guilherme Alvaro Hospital of Lusiada University Center

University Hospital of Jundiai Medical Faculty

Rio de Janeiro Federal University

Fluminense Federal University

Regional Hospital of Asa Norte Trophoblastic Disease Center, Distrito Federal

Julio Muller University Hospital of Mato Grosso Federal University Cuiaba

Regional Hospital of Mato Grosso do Sul. Campo Grande

University Hospital of Piaui Federal University

Pernambuco Institute of Maternal Child Health

Clinics Hospital of Pernambuco Federal University

Lauro Wanderley University Hospital of Paraiba Federal University

University Hospital of Alagoas Federal University

Januario Cicco Maternity School of Rio Grande do Norte University

Marly Sarney State Maternity

University Hospital of Sergipe Federal University

Climerio de Oliveira Maternity of Bahia Federal University

University Hospital of Campina Grande Federal University

Assis Chateaubriand Maternity School of Ceara Federal University

Dona Regina Maternity

Getulio Vargas University Hospital

Roraima General Hospital

Santa Casa de Misericordia do Para Foundation

Mae Luiza Women’s Hospital

Ary Pinheiro Hospital of Base

Clinics Hospital of Acre

Botucatu Trophoblastic Disease Center Clinics Hospital of Botucatu Medical School Sao Paulo State University