Author(s):
Estofolete, Cassia F. ; Banho, Cecilia A. ; Campos, Guilherme R.F. ; Marques, Beatriz C. ; Sacchetto, Livia ; Ullmann, Leila S. [UNESP] ; Possebon, Fabio S. [UNESP] ; Machado, Luana F. ; Syrio, Juliana D. ; Araújo Junior, João P. [UNESP] ; Bittar, Cintia [UNESP] ; Rahal, Paula [UNESP] ; Lobo, Suzana M.A. ; Ferreira, Helena Lage ; Vasilakis, Nikos ; Nogueira, Mauricio L.
Date: 2022
Persistent ID: http://hdl.handle.net/11449/233252
Origin: Oasisbr
Subject(s): COVID-19; SARS-CoV-2; Vaccine
Description
Made available in DSpace on 2022-05-01T06:02:16Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-07-01
The rapid development of efficacious and safe vaccines against coronavirus disease 2019 (COVID-19) has been instrumental in mitigating the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Moreover, the emergence of SARS-CoV-2 variants raised concerns on the efficacy of these vaccines. Herein, we report two cases of breakthrough infections with the P1 variant in patients vaccinated with CoronaVac, which is one of the two vaccines authorized for emergency use in the Brazilian immunization program. Our observations suggest that the vaccine reduced the severity of the disease and highlight the potential risk of illness following vaccination and subsequent infection with the P1 variant as well as for continued efforts to prevent and diagnose infection in vaccinated persons.
Laboratório de Pesquisas em Virologia (LPV) Medicine School of São José do Rio Preto (FAMERP)
Hospital de Base
Biotecnology Institute São Paulo State University (UNESP)
Intitute of Biosciences Languages and Exact Sciences São Paulo State University (UNESP)
Department of Veterinary Medicine FZEA-USP University of São Paulo (USP)
Department of Pathology University of Texas Medical Branch, 301 University Blvd
Sealy Center for Vector-Borne and Zoonotic Diseases University of Texas Medical Branch, 301 University Blvd
Center for Biodefense and Emerging Infectious Diseases University of Texas Medical Branch, 301 University Blvd
Center for Tropical Diseases University of Texas Medical Branch, 301 University Blvd
Institute for Human Infection and Immunity University of Texas Medical Branch, 301 University Blvd
Biotecnology Institute São Paulo State University (UNESP)
Intitute of Biosciences Languages and Exact Sciences São Paulo State University (UNESP)
