Author(s): de Souza, William Marciel ; Fumagalli, Marcilio Jorge ; Carrera, Jean Paul ; de Araujo, Jansen ; Cardoso, Jedson Ferreira ; de Carvalho, Cristiano [UNESP] ; Durigon, Edison Luiz ; Queiroz, Luzia Helena [UNESP] ; Faria, Nuno Rodrigues ; Murcia, Pablo R. ; Figueiredo, Luiz Tadeu Moraes
Date: 2022
Persistent ID: http://hdl.handle.net/11449/233426
Origin: Oasisbr
Subject(s): Bat-borne diseases; Paramyxoviridae; Paramyxovirus; Virus discovery
Made available in DSpace on 2022-05-01T08:44:38Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-11-01
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Medical Research Council
National Institutes of Health
Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhgág virus (KANV), Boe virus (BOEV), and Guató virus (GUATV). In this study, we classified these viruses as putative species into the Macrojêvirus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses.
World Reference Center for Emerging Viruses and Arboviruses and Department of Microbiology and Immunology University of Texas Medical Branch
Virology Research Center Ribeirão Preto Medical School University of São Paulo, Ribeirão Preto
Department of Zoology University of Oxford
Department of Research in Virology and Biotechnology Gorgas Memorial Institute of Health Studies
Institute of Biomedical Sciences University of São Paulo
Evandro Chagas Institute, Ministry of Health
Faculty of Veterinary Medicine São Paulo State University, Araçatuba
Department of Infectious Disease Epidemiology Imperial College London
MRC-University of Glasgow Centre for Virus Research
Faculty of Veterinary Medicine São Paulo State University, Araçatuba
FAPESP: 06/00572-0
FAPESP: 13/14929-1
FAPESP: 15/05778-5
FAPESP: 17/13981-0
FAPESP: 18/09383-3
FAPESP: 18/14389-0
FAPESP: 19/24251-9
Medical Research Council: MC_UU_12014/9
National Institutes of Health: R24 AI120942
