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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fondo Nacional de Desarrollo Científico y Tecnológico
The angiogenesis process is a phenomenon in which numerous molecules participate in the stimulation of the new vessels' formation from pre-existing vessels. Angiogenesis is a crucial step in tissue regeneration and recovery of organ and tissue function. Muscle diseases affect millions of people worldwide overcome the ability of skeletal muscle to self-repair. Pro-angiogenic therapies are key in skeletal muscle regeneration where both myogenesis and angiogenesis occur. These therapies have been based on mesenchymal stem cells (MSCs), exosomes, microRNAs (miRs) and delivery of biological factors. The use of different calls of biomaterials is another approach, including ceramics, composites, and polymers. Natural polymers are use due its bioactivity and biocompatibility in addition to its use as scaffolds and in drug delivery systems. One of these polymers is the natural rubber latex (NRL) which is biocompatible, bioactive, versatile, low-costing, and capable of promoting tissue regeneration and angiogenesis. In this review, the advances in the field of pro-angiogenic therapies are discussed.
São Paulo State University (UNESP), Botucatu Medical School, Botucatu
National Heart and Lung Institute Imperial College London
Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile
Department of Physiology Faculty of Pharmacy Universidad de Sevilla
University of Queensland, Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, QLD
Department of Pathology and Medical Biology University of Groningen University Medical Center Groningen
São Paulo State University (UNESP), School of Philosophy and Sciences, Marília
Federal Institute of São Paulo (IFSP), Avaré
São Paulo State University (UNESP), Science Faculty, Bauru
São Paulo State University (UNESP), Faculty of Pharmaceutical Sciences, Araraquara
São Paulo State University (UNESP), Botucatu Medical School, Botucatu
São Paulo State University (UNESP), School of Philosophy and Sciences, Marília
São Paulo State University (UNESP), Science Faculty, Bauru
São Paulo State University (UNESP), Faculty of Pharmaceutical Sciences, Araraquara
Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316
FAPESP: 2016/01743-5
FAPESP: 2017/21783-4
