Author(s): Morandim-Giannetti, Andreia de A. ; Cotinguiba, Fernando ; Regasini, Luis O. ; Frigieri, Mariana C. [UNESP] ; Varanda, Eliana Aparecida [UNESP] ; Coqueiro, Aline ; Kato, Massuo J. ; Bolzani, Vanderlan da Silva [UNESP] ; Furlan, Maysa [UNESP]
Date: 2014
Persistent ID: http://hdl.handle.net/11449/26248
Origin: Oasisbr
Subject(s): Piperaceae; Piper tuberculatum; (Z)-piplartine; mutagenic activated; Ames test
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.
Univ Estadual São Paulo, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil
Ctr Univ FEI, Dept Engn Quim, BR-09850901 Sao Bernardo do Campo, SP, Brazil
Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
Univ São Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 São Paulo, Brazil
Univ Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
