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Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2014-02-26T17:18:53Z No. of bitstreams: 1 WOS000220363200029.pdf: 614453 bytes, checksum: 0bea3ab6505bdc83189b3db61b9a4c2a (MD5)
Made available in DSpace on 2014-02-26T17:18:53Z (GMT). No. of bitstreams: 1 WOS000220363200029.pdf: 614453 bytes, checksum: 0bea3ab6505bdc83189b3db61b9a4c2a (MD5) Previous issue date: 2004-04-01
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T15:29:48Z No. of bitstreams: 1 WOS000220363200029.pdf: 614453 bytes, checksum: 0bea3ab6505bdc83189b3db61b9a4c2a (MD5)
Made available in DSpace on 2014-05-20T15:29:48Z (GMT). No. of bitstreams: 1 WOS000220363200029.pdf: 614453 bytes, checksum: 0bea3ab6505bdc83189b3db61b9a4c2a (MD5) Previous issue date: 2004-04-01
Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of insertion sequence elements. Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. A broad array of transcriptional regulation proteins and two new families of afimbrial adhesins which contribute to host tissue colonization in the early steps of infection were identified. Differences in genes involved in the biosynthesis of lipopolysaccharide 0 side chains between the Copenhageni and Lai serovars were identified, offering an important starting point for the elucidation of the organism's complex polysaccharide surface antigens. Differences in adhesins and in lipopolysaccharide might be associated with the adaptation of serovars Copenhageni and Lai to different animal hosts. Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identified as candidates for development of vaccines for the prevention of leptospirosis.
Univ São Paulo, Ctr Biotechnol, Inst Butantan, BR-05503900 São Paulo, SP, Brazil
Univ São Paulo, Inst Quim, São Paulo, Brazil
Univ São Paulo, Inst Ciências Biomed, BR-05508 São Paulo, Brazil
Univ São Paulo, Inst Biociencias, São Paulo, Brazil
Univ São Paulo, Inst Biol, São Paulo, Brazil
Univ São Paulo, Piracicaba, Brazil
Univ Estadual Paulista, Fac Ciências Agrarias & Vet, Jaboticabal, Brazil
Univ Fed Sao Carlos, Ctr Ciências Agrarias, Araras, Brazil
Fac Ciências Farmaceut, Ribeirao Preto, Brazil
Fac Filosofia Ciências & Letras, Ribeirao Preto, Brazil
Univ São Paulo, BR-14049 Ribeirao Preto, Brazil
Univ Mogi Cruzes, Fac Ciências Agron, Mogi Cruzes, Brazil
Univ Mogi Cruzes, Inst Biociencias, Mogi Cruzes, Brazil
Univ Estadual Paulista, Botucatu, SP, Brazil
Univ Mogi Cruzes, Nucleo Integrado Biotecnol, Mogi Das Cruzes, Brazil
Univ Estadual Paulista, Dept Genet & Evolucao, Campinas, SP, Brazil
Univ Estadual Paulista, Inst Computacao, Campinas, SP, Brazil
Univ Estadual Paulista, Inst Agron Campinas, Campinas, SP, Brazil
Univ Estadual Paulista, Ctr Biol Mol & Engn Genet, Campinas, SP, Brazil
Univ Fed Bahia, Serv Immunol, BR-41170290 Salvador, BA, Brazil
UEFS, LAPEM, Dept Ciências Biol, Feira de Santana, BA, Brazil
Inst Oswaldo Cruz, Dept Bioquim & Biol Mol, BR-20001 Rio de Janeiro, Brazil
Univ Fed Pelotas, Ctr Biotechnol, Pelotas, Brazil
Univ Fed Rio Grande Norte, Ctr Biociencias, BR-59072970 Natal, RN, Brazil
Cornell Univ, Weill Med Coll, Div Int Med & Infect Dis, New York, NY USA
Ludwig Inst Canc Res, New York, NY USA
Univ Calif Los Angeles, Sch Med, Los Angeles, CA USA
Vet Affairs Greater Los Angeles Healthcare Syst, Div Infect Dis, Los Angeles, CA USA
Koninklin Inst Tropen, Royal Trop Inst, KIT Biomed Res, Amsterdam, Netherlands
Univ Estadual Paulista, Fac Ciências Agrarias & Vet, Jaboticabal, Brazil
Univ Estadual Paulista, Botucatu, SP, Brazil
Univ Estadual Paulista, Dept Genet & Evolucao, Campinas, SP, Brazil
Univ Estadual Paulista, Inst Computacao, Campinas, SP, Brazil
Univ Estadual Paulista, Inst Agron Campinas, Campinas, SP, Brazil
Univ Estadual Paulista, Ctr Biol Mol & Engn Genet, Campinas, SP, Brazil
