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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
COLCIENCIAS
Ministry of Social Protection
National Institute of Allergy and Infectious Diseases (NIAID)
We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved.
Univ Fed Sergipe, Dept Biociencias, BR-49500000 Itabaiana, SE, Brazil
Faculdade de Medicina de São José do Rio Preto (FAMERP), Dept Doencas Dermatol Infecciosas & Parasitarias, Ctr Invest Microrganismos, BR-15090000 São Paulo, Brazil
Univ Fed Triangulo Mineiro, Inst Ciencias Exatas Nat & Educ, BR-38025180 Uberaba, MC, Brazil
Univ Estadual Paulista, BR-15054000 São Paulo, Brazil
Nucleo Estadual Amapa CRDT, Minist Saude, BR-68900430 Macapa, Amapa, Brazil
Secretaria Vigilancia Saude, Inst Evandro Chagas, Lab Pesquisas Basicas Malaria, BR-6703000 Ananindeua, Para, Brazil
Univ São Paulo, Fac Ciencias Farmaceut, BR-05508900 São Paulo, Brazil
Fundação Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Malaria, BR-30190002 Belo Horizonte, MG, Brazil
Univ Valle, Fac Salud, Inst Inmunol, Cali, Colombia
Univ Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, BR-24210130 Rio de Janeiro, Brazil
Faculdade de Medicina de São José do Rio Preto (FAMERP), Dept Epidemiol, BR-15090000 São Paulo, Brazil
Faculdade de Medicina de São José do Rio Preto (FAMERP), Dept Biol Mol, Lab Imunohematol, BR-15090000 São Paulo, Brazil
Univ Estadual Paulista, BR-15054000 São Paulo, Brazil
FAPESP: 02/09546-1
FAPESP: 06/09546-1
CNPq: 302353/03-8
CNPq: 410405/2006-0
COLCIENCIAS: 1106-04-16489)
Ministry of Social Protection: 2304-04-19524
Ministry of Social Protection: 253-2005
National Institute of Allergy and Infectious Diseases (NIAID): 49486/TMRC
