Document details

A new imidazole alkaloid and other constituents from Pilocarpus grandiflorus and their antifungal activity

Author(s): De Souza, Rejane C. ; Fernandes, João B. ; Vieira, Paulo C. ; Da Silva, M. Fátima Das G. F. ; Godoy, Marizete F. P. [UNESP] ; Pagnocca, Fernando C. [UNESP] ; Bueno, Odair C. [UNESP] ; Hebling, M. José A. [UNESP] ; Pirani, José R.

Date: 2014

Persistent ID: http://hdl.handle.net/11449/68335

Origin: Oasisbr

Subject(s): Atta sexdens rubropilosa; Imidazole Alkaloid; Jaborandi; Leucoagaricus gongylophorus; Pilocarpus grandiflorus


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The stems of Pilocarpus grandiflorus have afforded the new imidazole alkaloid 4,6-dehydro-1,2,4,5-tetrahydro-2,5-dioxopilocarpine in addition to the 17 known compounds germanicol, β-amiryn, ocotillone, stigmast-4-en-3-one, 3β-hydroxy-stigmast-5-en-7-one, 6β-hydroxy-stigmast-4-en-3-one, β-sitosterol, scopoletin, 3-(1′,1′-dimethylallyl)-scopoletin, elisin, dictamine, 4-methoxy-2-quinolone, platydesmine, syringaresinol, syringaldehyde, syringic acid and vanillic acid. Their structures were elucidated on the basis of chemical and spectroscopic evidence. The phenolic compounds vanillic acid and syringaldehyde and the furoquinoline alkaloid platydesmine exhibited antifungal activity against Leucoagaricus gongylophorus, the symbiotic fungus of leaf-cutting ants (Atta sexdens rubropilosa). © 2005 Verlag der Zeitschrift für Naturforschung.

Departamento de Química Universidade Federal de São Carlos, Caixa Postal 676, São Carlos, SP

Centro de Estudos de Insetos Sociais Universidade Estadual Paulista, Rio Claro, SP

Departamento de Botanica Instituto de Biociencias Universidade de São Paulo, São Paulo - SP

Centro de Estudos de Insetos Sociais Universidade Estadual Paulista, Rio Claro, SP

Document Type Journal article
Language English
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