Autor(es):
Carli, Camila B. de A. [UNESP] ; De Matos, Djamile C. [UNESP] ; Lopes, Flávia C. M. [UNESP] ; Maia, Danielle C. G. [UNESP] ; Dias, Maristela B. [UNESP] ; Sannomiya, Miriam [UNESP] ; Rodrigues, Clenilson M. [UNESP] ; Andreo, Marcio A. [UNESP] ; Vilegas, Wagner [UNESP] ; Colombo, Lucas L. ; Carlos, Iracilda Zeppone [UNESP]
Data: 2014
Identificador Persistente: http://hdl.handle.net/11449/70961
Origem: Oasisbr
Assunto(s): Antitumour activity; Cytokine; Flavonoids; antineoplastic agent; cisplatin; flavonoid; animal; Bagg albino mouse; cell survival; drug effect; experimental neoplasm; female; isolation and purification; Malpighiaceae; mouse; Myrtaceae; pathology; tumor cell line; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cisplatin; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Byrsonima crassa; Davilla; Mouriri; Murinae; Pusa
Descrição
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
The purpose of the present study was to investigate antitumour and anti-inflammatory activities of flavonoids isolated from Byrsonima crassa, Davilla elliptica and Mouriri pusa. The antitumour activity was measured by the MTT assay in murine mammary tumour cells (LM2) and the IC 50 values of the flavonoids tested ranged from (31.5 ± 2.97) to (203.1 ± 5.9) μg/ml. The flavonoids 1 (myricetin-3-O-α-L-rhamnopyranoside) and 3 (quercetin-3-O-galactopyranoside) from D. elliptica were the most active ones against the tumour cells. The same samples were tested to determine the inhibition of the release of nitric oxide (NO) and of the tumour necrosis factor-alpha (TNF-α) in murine macrophages by the Griess and ELISA sandwich assay, respectively. Almost all the samples showed inhibitory activity to the release of NO but not of TNF-α. Of all substances tested, flavonoids 2 (quercetin) and 6 (myricetin) may show promising activity in the treatment of murine breast cancer by immunomodulatory and antiproliferative activities. © 2009 Verlag der Zeitschrift für Naturforschung.
UNESP São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP
UNESP São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP
Buenos Aires University Instituto de Oncologia UBA, Buenos Aires
UNESP São Paulo State University Faculdade de Ciências Farmacêuticas, C. Postal 502, 14801-902, Araraquara, SP
UNESP São Paulo State University Instituto de Química de Araraquara, C. Postal 355, 14801-970, Araraquara, SP
FAPESP: 02/05503-6
