Autor(es):
Ondei, L. S. [UNESP] ; Silveira, L. M. [UNESP] ; Leite, Amauri Antiquera [UNESP] ; Souza, D. R S ; Pinhel, M. A S ; Percário, S. ; Ricci, O. ; Bonini-Domingos, C. R. [UNESP]
Data: 2014
Identificador Persistente: http://hdl.handle.net/11449/71373
Origem: Oasisbr
Assunto(s): G6PD deficiency; Oxidative stress; TBARS; TEAC; glucose 6 phosphate dehydrogenase; thiobarbituric acid reactive substance; trolox C; adolescent; adult; aged; antioxidant activity; blood sampling; colorimetry; controlled study; female; gene mutation; glucose 6 phosphate dehydrogenase deficiency; human; lipid peroxidation; major clinical study; male; oxidative stress; sex difference; trolox equivalent antioxidant capacity; Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants; Base Sequence; DNA Primers; Female; Glucosephosphate Dehydrogenase Deficiency; Humans; Lipid Peroxidation; Male; Middle Aged; Mutation; Young Adult
Descrição
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Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five hundred and forty-four peripheral blood samples were screened for G6PD deficiency; we also analyzed lipid peroxidation products measured as thiobarbituric acid reactive species and Trolox equivalent antioxidant capacity. Men with the A-(202G>A) mutation had lower G6PD activity than women with the same mutation. Individuals with the A-(202G>A) mutation also differed in mean Trolox equivalent antioxidant capacity values but not for thiobarbituric acid reactive species values. We concluded that A-(202G>A) mutation is associated with reduced G6PD activity and increased Trolox equivalent antioxidant capacity. ©FUNPEC-RP.
Departamento de Biologia Instituto de Biociências, Letras e Ciências Exatas Universidade Estadual Paulista, São José do Rio Preto, SP
Departamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Araraquara, SP
Departamento de Biologia Molecular Laboratório de Bioquímica e Biologia Molecular Faculdade de Medicina de São José do Rio Preto, SP
Instituto de Ciências Biológicas, Núcleo de Medicina Tropical Universidade Federal do Pará, Belém, PA
Hemocentro, São José do Rio Preto, SP
Departamento de Biologia Instituto de Biociências, Letras e Ciências Exatas Universidade Estadual Paulista, São José do Rio Preto, SP
Departamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Araraquara, SP
