Author(s):
Reis, Leonardo Oliveira ; Sopena, Josep Maria Gaya ; Fávaro, Wagner José [UNESP] ; Martin, Mireia Castilho ; Simão, Antônio Felipe Leite ; Reis, Rodolfo Borges dos ; Andrade, Murilo Ferreira de ; Domenech, Josep Domingo ; Cardo, Carlos Cordon
Date: 2014
Persistent ID: http://hdl.handle.net/11449/72792
Origin: Oasisbr
Subject(s): Anatomy; Rats; Rodent diseases; Urinary tract; animal anatomy; animal experiment; bladder; bladder catheterization; cancer research; carcinogenesis; cost benefit analysis; female; mouse; nonhuman; rat; toxicity testing; urethra; urethral catheterization; vesicoureteral reflux; Animals; Female; Medical Illustration; Mice; Models, Animal; Reproducibility of Results; Sex Factors; Urethra; Urinary Bladder; Urinary Catheterization
Description
Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:26:07Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:47:24Z : No. of bitstreams: 1 2-s2.0-80555124917.pdf: 4836061 bytes, checksum: 14e9e88fa4369888766c893b3fcde127 (MD5)
Made available in DSpace on 2014-05-27T11:26:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-11-10
PURPOSE: To present fundamental anatomical aspects and technical skills necessary to urethra and urinary bladder catheterization in female mice and rats. METHODS: Urethral and bladder catheterization has been widely utilized for carcinogenesis and cancer research and still remains very useful in several applications: from toxicological purposes as well as inflammatory and infectious conditions to functional aspects as bladder dynamics and vesicoureteral reflux, among many others. RESULTS: Animal models are in the center of translational research and those involving rodents are the most important nowadays due to several advantages including human reproducibility, easy handling and low cost. CONCLUSIONS: Although technical and anatomical pearls for rodent urethral and bladder access are presented as tackles to the advancement of lower urinary tract preclinical investigation in a broaden sight, restriction to female animals hampers the male microenvironment, demanding future advances.
Urologic Oncology Division Department of Urology University of Campinas (UNICAMP), Campinas-SP
Herbert Irving Comprehensive Cancer Center Columbia University, New York, NY
Department of Anatomy, Institute of Biosciences Universidade Estadual Paulista (UNESP), Botucatu-SP
Division of Urology Department of Surgery and Anatomy, Ribeirao Preto-SP
Urologic Division Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP
Herbert Irving Comprehensive Cancer Center Columbia University, New York, New York
Department of Anatomy, Institute of Biosciences Universidade Estadual Paulista (UNESP), Botucatu-SP
