Autor(es): Pavan, Fernando Rogério [UNESP] ; Leite, Clarice Queico Fujimura [UNESP] ; Coelho, Roberta Gomes ; Coutinho, Isabel Duarte ; Honda, Neli Kika ; Cardoso, Claudia Andréa Lima ; Vilegas, Wagner [UNESP] ; Leite, Sergio Roberto de Andrade [UNESP] ; Sato, Daisy Nakamura
Data: 2014
Identificador Persistente: http://hdl.handle.net/11449/8029
Origem: Oasisbr
Assunto(s): Campomanesia adamantium; anti-Mycobacterium tuberculosis; flavonoids
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
The anti-Mycobacterium tuberculosis activity of Campomanesia adamantium fruits extracts were evaluated. Six compounds, identified as flavanones and chalcones were quantified by HPLC-DAD-UV. Promising antitubercular activity was observed with ethyl acetate extract (MIC 62.5 µg/mL) and their fractions (MIC values ranging from 39 to above 250 µg/mL). The better MIC result of 39 µg/mL was associated with two fractions that contain bigger amounts of 5,7-dihydroxy-6, 8-di-C-methylflavanone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone. These compounds exhibited MICs >250 and 62.5 µg/mL, respectively, while their mixtures showed values ranging from 62.5 to 7.8 µg/mL, demonstrating a synergism between them.
Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Ciências Biológicas
Universidade Federal de Mato Grosso do Sul Departamento de Química
Universidade Federal de Mato Grosso do Sul Curso de Química
Universidade Estadual Paulista Instituto de Química Departamento de Química
Instituto Adolfo Lutz de Ribeirão Preto
Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Ciências Biológicas
Universidade Estadual Paulista Instituto de Química Departamento de Química
