Autor(es): Pallos, Débora ; Leao, Mariella V. P. ; Togeiro, Fernanda C. F. B. ; Alegre, Larissa ; Ricardo, Lucilene Hernandes ; Perozini, Caroline ; Ruivo, Gilson Fernandes
Data: 2019
Origem: Oasisbr
Assunto(s): Saliva; Chronic Renal Failure; Inflammation; Markers; Leukocyte Activation; Disease; Inflammation; Dialysis; Hemodialysis; Malnutrition; Association; Disorders; Serum; Risk; Dentistry, Oral Surgery & Medicine; Dentistry, Oral Surgery & Medicine
Made available in DSpace on 2019-09-12T16:53:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2015
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Introduction: Chronic renal failure (CRF) is a progressive loss of renal function over a period of months or years. The major function of the kidneys is the removal of metabolic waste products, electrolytes and water. When this function is impaired, systemic changes, oral complications and alterations in salivary composition may occur. Objective: This study aimed to compare the levels of immunological and inflammatory components in the saliva samples from patients that undergo to hemodialysis treatment (HD), without HD and control. Design: This study evaluated IgA, IgG, C reactive protein (CRP) and nitric oxide (NO) in saliva samples from 119 patients, who were divided into the control group (C), chronic renal failure (CRF) patient group and CRF patients on hemodialysis treatment (HD) group. IgA and IgG levels were analyzed by ELISA. Nitric oxide levels were determined indirectly by the nitrite concentration using Griess reagent; CRP by agglutination tests; and total proteins, by Bradford assay. Results: The HD group showed significantly higher levels of IgG, IgA and CRP compared with the control and CRF groups. The CRF group presented the same amounts of IgG, IgA and CRP as the C group but significantly higher levels of NO similar to the HD group. Conclusion: Renal disease, particularly hemodialysis treatment during renal disease, seems to alter salivary immunological and inflammatory components. Thus, analyzing the levels of IgA, IgG, NO and CRP in saliva may be beneficial for monitoring renal disease. (C) 2015 Elsevier Ltd. All rights reserved.
[Pallos, Debora] Univ Santo Amaro, Implantol Dept, Sao Paulo, Brazil
[Pallos, Debora; Togeiro, Fernanda C. F. B.; Alegre, Larissa; Perozini, Caroline] Universidade de Taubaté (Unitau), Dept Periodont
[Leao, Mariella V. P.] Universidade de Taubaté (Unitau), Basic Biosci Inst
[Leao, Mariella V. P.] Universidade de Taubaté (Unitau), Biosci & Oral Diag
[Ricardo, Lucilene Hernandes] Private Off, Pindamonhangaba, Brazil
[Ruivo, Gilson Fernandes] Universidade de Taubaté (Unitau), Dept Med
