Genetic linkage of hereditary gingival fibromatosis to chromosome 2p21

• Autor(es): Hart, Thomas Charles ; Pallos, Débora ; Bowden, Donald W ; Bolyard, Joey ; Pettenati, Mark J ; Cortelli, José Roberto
• Data: 2019
• Origem: Oasisbr
• Assunto(s): Drug-Induced Gingival; Overgrowth; Maps; Genetics & Heredity; Genetics & Heredity
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

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National Institute of Dental and Craniofacial Research (NIDCR)

Gingival fibromatosis is characterized by a slowly progressive benign enlargement of the oral gingival tissues. The condition results in the teeth being partially or totally engulfed by keratinized gingiva, causing aesthetic and functional problems. Both genetic and pharmacologically induced forms of gingival fibromatosis are known. The most common genetic form, hereditary gingival fibromatosis (HGF), is usually transmitted as an autosomal dominant trait, although sporadic cases are common and autosomal recessive inheritance has been reported. The genetic basis of gingival fibromatosis is unknown. We identified an extended family (n = 32) segregating an autosomal dominant form of isolated gingival fibromatosis. Using a genomewide search strategy, we identified genetic linkage (Z(max) = 5.05, theta = .00) for the HGF phenotype to polymorphic markers in the genetic region of chromosome 2p21 bounded by the loci D2S1788 and D2S441. This is the first report of linkage for isolated HGF, and the findings have implications for identification of the underlying genetic basis of gingival fibromatosis.

Wake Forest Univ, Bowman Gray Sch Med, Dept Pediat, Med Genet Sect, Winston Salem, NC 27157 USA; Wake Forest Univ, Bowman Gray Sch Med, Dept Dent, Winston Salem, NC 27157 USA; Wake Forest Univ, Bowman Gray Sch Med, Dept Biochem, Winston Salem, NC 27157 USA; Universidade de Taubaté (Unitau), Dept Dent, Sao Paulo, Brazil