Author(s): Morgado, Pedro ; Silva, Miguel ; Sousa, Nuno ; Cerqueira, João José
Date: 2012
Persistent ID: http://hdl.handle.net/1822/19900
Origin: RepositóriUM - Universidade do Minho
Project/scholarship: info:eu-repo/grantAgreement/FCT/5876-PPCDTI/111814/PT ; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FSINTD%2F60129%2F2009/PT;
Subject(s): Stress; Conditioning; Pavlovian-to-instrumental transfer; Choices; Science & Technology
Stress has a strong impact in the brain, impairing decision-making processes as a result of changes in circuits involving the prefrontal and orbitofrontal cortices and the striatum. Given that these same circuits are key for action control and outcome encoding, we hypothesized that adaptive responses to which these are essential functions, could also be targeted by stress. To test this hypothesis we herein assessed the impact of chronic stress in a Pavlovian-to-instrumental transfer (PIT) paradigm, a model of an adaptive response in which a previously conditioned cue biases an instrumental goal-directed action. Data reveals that rats submitted to chronic unpredictable stress did not display deficits in pavlovian conditioning nor on the learning of the instrumental task, but were impaired in PIT; importantly, after a stress-free period the PIT deficits were no longer observed. These results are relevant to understand how stress biases multiple incentive processes that contribute to instrumental performance.
Fundação para a Ciência e a Tecnologia (FCT) - SFRH/SINTD/60129/2009, PTDC/SAU-NSC/111814/2009 FEDER
FEDER - Operational program for competitivity factors – COMPETE
