Detalhes do Documento

The bounds of education in the human brain connectome

Autor(es): Marques, Paulo César Gonçalves ; Soares, José Miguel Montenegro ; Magalhaes, Ricardo José da Silva ; Santos, Nadine Correia ; Sousa, Nuno

Data: 2015

Identificador Persistente: http://hdl.handle.net/1822/40679

Origem: RepositóriUM - Universidade do Minho

Projeto/bolsa: info:eu-repo/grantAgreement/EC/FP7/259772/EU; info:eu-repo/grantAgreement/FCT/3599-PPCDT/127675/PT ;

Assunto(s): Ciências Médicas::Ciências da Saúde; Science & Technology


Descrição

Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.

This work was funded by the European Commission (FP7): “SwitchBox” (Contract HEALTH-F2-2010-259772) and co-financed by the Portuguese North Regional Operational Program (ON.2 – O Novo Norte) under the National Strategic Reference Framework (QREN), through the European Regional Development Fund (FEDER). José M. Soares, Paulo Marques, and Nadine C. Santos are supported by fellowships of the project “SwitchBox”; Ricardo Magalhães is supported by a fellowship from the project FCT ANR/NEU-OSD/0258/2012 funded by FCT/MEC (www.fct.pt) and by ON.2 – ONOVONORTE – North Portugal Regional Operational Programme 2007/2013, of the National Strategic Reference Framework (NSRF) 2007/2013, through FEDER.

Tipo de Documento Artigo científico
Idioma Inglês
Contribuidor(es) Universidade do Minho
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