In vitro and computational studies of transdermal perfusion of nanoformulations containing a large molecular weight protein

• Author(s): Martins, Margarida Isabel Barros Coelho ; Azóia, Nuno G. ; Ribeiro, Artur J. ; Shimanovich, Ulyana ; Silva, Carla Manuela Pereira Marinho da ; Paulo, Artur Cavaco
• Date: 2013
• Persistent ID: https://hdl.handle.net/1822/24342
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Protein; Surfactant; Nanodispersion; Transdermal perfusion; Hydrophilic macromolecules
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Transdermal perfusion of a large protein is reported for the first time, using a nanoemulsion of bovine serum albumin (66 kDa) of 160 nm prepared by a solid-in-oil (S/O) process. Molecular dynamics simulations confirmed skin permeation by these formulations, with integration of the protein into the lipid bilayers. These results demonstrate the real possibility of delivering large proteins transdermally for a range of medical and cosmetic applications.