Author(s): Menino, João Filipe ; Saraiva, Margarida ; Alves, Ana G. Gomes ; Lobo-Silva, Diogo ; Sturme, Mark H. J. ; Gomes, Jéssica Angélica Rezende ; Saraiva, Ana Laura ; Goldman, Gustavo H. ; Cunha, Cristina ; Carvalho, Agostinho ; Romani, Luigina ; Pedrosa, Jorge ; Castro, António Gil ; Rodrigues, Fernando
Date: 2013
Persistent ID: https://hdl.handle.net/1822/25192
Origin: RepositóriUM - Universidade do Minho
Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both TLR2 and TLR4 have been implicated in the recognition of P. brasiliensis and regulation of the immune response. However, the role of TLR9 during the infection by this fungus remains unclear.
