Synthetic Protein Biotechnology approaches for the creation of antimicrobial biopolymers

• Author(s): Costa, André Manuel Abreu ; Machado, Raul ; Ribeiro, Artur J. ; Collins, Tony ; Thiagarajan, V. ; Neves-Petersen, M.T. ; Rodríguez-Cabello, J.C. ; Gomes, Andreia C ; Casal, Margarida
• Date: 2015
• Persistent ID: https://hdl.handle.net/1822/46188
• Origin: RepositóriUM - Universidade do Minho
• Document Type: Other
• Language: English
• Contributor(s): Universidade do Minho

Description

[Excerpt] The spread of antimicrobials resistant microorganisms has triggered the search for new ways to treat infections. In the present work we explored the ABP-CM4 peptide properties from Bombyx mori for the creation of biopolymers with broad antimicrobial activity. An antimicrobial recombinant protein-based polymer (rPBP) was designed by cloning the DNA sequence coding for ABP-CM4 in frame with the N-terminus of the elastin-like recombinamer consisting of 200 repetitions of the pentamer VPAVG, here named A200. [...]