A complex scenario of tuberculosis transmission is revealed through genetic and epidemiological surveys in Porto

• Author(s): Rito, Teresa S ; Matos, Carlos ; Carvalho, Carlos ; Machado, Henrique Pedro Pereira Silva Amaral ; Rodrigues, Gabriela ; Oliveira, Olena ; Ferreira, Eduarda ; Gonçalves, Jorge ; Maio, Lurdes ; Morais, Clara ; Ramos, Helena ; Guimarães, João Tiago ; Santos, Catarina L. ; Duarte, Raquel ; Correia-Neves, M
• Date: 2018
• Persistent ID: https://hdl.handle.net/1822/57932
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Female; Genotype; Humans; Minisatellite Repeats; Molecular Epidemiology; Mycobacterium tuberculosis; Portugal; Socioeconomic Factors; Tuberculosis; Genotyping techniques; Epidemiology of tuberculosis; Phylogenetic analysis; Public health
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Tuberculosis (TB) incidence is decreasing worldwide and eradication is becoming plausible. In low-incidence countries, intervention on migrant populations is considered one of the most important strategies for elimination. However, such measures are inappropriate in European areas where TB is largely endemic, such as Porto in Portugal. We aim to understand transmission chains in Porto through a genetic characterization of Mycobacterium tuberculosis strains and through a detailed epidemiological evaluation of cases.