Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

• Author(s): Ruesen, Carolien ; Chaidir, Lidya ; van Laarhoven, Arjan ; Dian, Sofiati ; Ganiem, Ahmad Rizal ; Guimarães, Hanna Nebenzahl ; Huynen, Martijn A. ; Alisjahbana, Bachti ; Dutilh, Bas E. ; van Crevel, Reinout
• Date: 2018
• Persistent ID: https://hdl.handle.net/1822/58062
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Computational Biology; Genomics; Humans; Indonesia; Mycobacterium tuberculosis; Phenotype; Phylogeny; Polymorphism, Single Nucleotide; Tuberculosis, Meningeal; Tuberculosis, Pulmonary; Genes, Bacterial; Genetic Variation; Genome, Bacterial; Pulmonary tuberculosis; Tuberculous meningitis; Whole genome sequencing; Homoplasy
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.