PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

• Author(s): Munari, Fernanda Franco ; Cruvinel-Carloni, Adriana ; Lacerda, Croider Franco ; de Oliveira, Antônio Talvane Torres ; Scapulatempo-Neto, Cristovam ; da Silva, Sandra Regina Morini ; Crema, Eduardo ; Adad, Sheila Jorge ; Rodrigues, Maria Aparecida Marchesan ; Henry, Maria Aparecida Coelho Arruda ; Guimarães, Denise Peixoto ; Longatto, Adhemar ; Reis, R. M.
• Date: 2018
• Persistent ID: https://hdl.handle.net/1822/59781
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): Esophageal cancer; Trypanosoma cruzition; Achalasia; Esophageal squamous cell carcinoma; Chagasic megaesophagus; PIK3CA; Mutation; Trypanosoma cruzi
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

Chronic diseases such as chagasic megaesophagus (secondary to Chagas' disease) have been suggested as etiological factors for esophageal squamous cell carcinoma; however, the molecular mechanisms involved are poorly understood.